User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Semiautomatic methods for segmentation of the proliferative tumour volume on sequential FLT PET/CT images in head and neck carcinomas and their relation to clinical outcome

Primary tabs

Arens, Anne I. J. Troost, Esther G. C. Hoeben, Bianca A. W. Grootjans, Willem Lee, John Aldo [UCL] Grégoire, Vincent [UCL] Visser, Eric P.

(eng) Purpose: Radiotherapy of head and neck cancer induces changes in tumour cell proliferation during treatment, which can be depicted by the PET tracer 18F-fluorothymidine (FLT). In this study, three advanced semiautomatic PET segmentation methods for delineation of the proliferative tumour volume (PV) before and during (chemo)radiotherapy were compared and related to clinical outcome. Methods: The study group comprised 46 patients with 48 squamous cell carcinomas of the head and neck, treated with accelerated (chemo)radiotherapy, who underwent FLT PET/CT prior to treatment and in the 2nd and 4th week of therapy. Primary gross tumour volumes were visually delineated on CT images (GTVCT). PVs were visually determined on all PET scans (PVVIS). The following semiautomatic segmentation methods were applied to sequential PET scans: background-subtracted relative-threshold level (PVRTL), a gradient-based method using the watershed transform algorithm and hierarchical clustering analysis (PVW&C), and a fuzzy locally adaptive Bayesian algorithm (PVFLAB). Results: Pretreatment PVVIS correlated best with PVFLAB and GTVCT. Correlations with PVRTL and PVW&C were weaker although statistically significant. During treatment, the PV VIS, PVW&C and PVFLAB significant decreased over time with the steepest decline over time for PVFLAB. Among these advanced segmentation methods, PVFLAB was the most robust in segmenting volumes in the third scan (67 % of tumours as compared to 40 % for PVW&C and 27 % for PVRTL). A decrease in PV FLAB above the median between the pretreatment scan and the scan obtained in the 4th week was associated with better disease-free survival (4 years 90 % versus 53 %). Conclusion: In patients with head and neck cancer, FLAB proved to be the best performing method for segmentation of the PV on repeat FLT PET/CT scans during (chemo)radiotherapy. This may potentially facilitate radiation dose adaptation to changing PV.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "European Journal of Nuclear Medicine and Molecular Imaging" - Vol. 41, no. 5, p. 915-924 (2014)
Peer reviewed yes
Publisher Springer-Verlag ((Germany) Berlin)
issn 1619-7070
e-issn 1619-7089
Publication status Publié
Affiliations UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Service de radiothérapie oncologique
UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Links
  1. Hermans Robert, Feron Michel, Bellon Erwin, Dupont Patrick, Van den Bogaert Walter, Baert Albert L., Laryngeal tumor volume measurements determined with CT: A study on intra- and interobserver variability, 10.1016/s0360-3016(97)00853-5
  2. Kim John J., Tannock Ian F., Repopulation of cancer cells during therapy: an important cause of treatment failure, 10.1038/nrc1650
  3. Troost E. G. C., Bussink J., Hoffmann A. L., Boerman O. C., Oyen W. J. G., Kaanders J. H. A. M., 18F-FLT PET/CT for Early Response Monitoring and Dose Escalation in Oropharyngeal Tumors, 10.2967/jnumed.109.069310
  4. Bonner James A., Harari Paul M., Giralt Jordi, Azarnia Nozar, Shin Dong M., Cohen Roger B., Jones Christopher U., Sur Ranjan, Raben David, Jassem Jacek, Ove Roger, Kies Merrill S., Baselga Jose, Youssoufian Hagop, Amellal Nadia, Rowinsky Eric K., Ang K. Kian, Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck, 10.1056/nejmoa053422
  5. Overgaard Jens, Hansen Hanne Sand, Specht Lena, Overgaard Marie, Grau Cai, Andersen Elo, Bentzen Jens, Bastholt Lars, Hansen Olfred, Johansen Jørgen, Andersen Lisbeth, Evensen Jan F, Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial, 10.1016/s0140-6736(03)14361-9
  6. Shields Anthony F., Grierson John R., Dohmen Bernhard M., Machulla H.-Juergen, Stayanoff Joseph C., Lawhorn-Crews Jawana M., Obradovich Joyce E., Muzik Otto, Mangner Thomas J., Imaging proliferation in vivo with [F-18]FLT and positron emission tomography, 10.1038/3337
  7. van Waarde A, Cobben DC, Suurmeijer AJ, Maas B, Vaalburg W, de Vries EF, et al. Selectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model. J Nucl Med. 2004;45:695–700.
  8. Menda Y., Boles Ponto L. L., Dornfeld K. J., Tewson T. J., Watkins G. L., Schultz M. K., Sunderland J. J., Graham M. M., Buatti J. M., Kinetic Analysis of 3'-Deoxy-3'-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy, 10.2967/jnumed.108.058495
  9. Hoeben B. A. W., Troost E. G. C., Span P. N., van Herpen C. M. L., Bussink J., Oyen W. J. G., Kaanders J. H. A. M., 18F-FLT PET During Radiotherapy or Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma Is an Early Predictor of Outcome, 10.2967/jnumed.112.105999
  10. Everitt Sarah, Hicks Rodney J., Ball David, Kron Tomas, Schneider-Kolsky Michal, Walter Tania, Binns David, Mac Manus Michael, Imaging Cellular Proliferation During Chemo-Radiotherapy: A Pilot Study of Serial 18F-FLT Positron Emission Tomography/Computed Tomography Imaging for Non–Small-Cell Lung Cancer, 10.1016/j.ijrobp.2008.12.039
  11. de Langen Adrianus J., Klabbers Bianca, Lubberink Mark, Boellaard Ronald, Spreeuwenberg Marieke D., Slotman Ben J., de Bree Remco, Smit Egbert F., Hoekstra Otto S., Lammertsma Adriaan A., Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography, 10.1007/s00259-008-0960-5
  12. Boles Ponto Laura L., Menda Yusuf, Dornfeld Kenneth, Tewson Timothy J., Watkins G. Leonard, Sunderland John, Graham Michael M., Buatti John, Stability of 3′-Deoxy-3′-[18F]Fluorothymidine Standardized Uptake Values in Head and Neck Cancer Over Time, 10.1089/cbr.2009.0709
  13. Daisne Jean-François, Sibomana Mérence, Bol Anne, Doumont Thomas, Lonneux Max, Grégoire Vincent, Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: influence of reconstruction algorithms, 10.1016/s0167-8140(03)00270-6
  14. van Dalen Jorn A., Hoffmann Aswin L., Dicken Volker, Vogel Wouter V., Wiering Bastiaan, Ruers Theo J., Karssemeijer Nico, Oyen Wim J.G., A novel iterative method for lesion delineation and volumetric quantification with FDG PET : , 10.1097/mnm.0b013e328155d154
  15. Geets Xavier, Lee John A., Bol Anne, Lonneux Max, Grégoire Vincent, A gradient-based method for segmenting FDG-PET images: methodology and validation, 10.1007/s00259-006-0363-4
  16. Hatt Mathieu, Cheze le Rest Catherine, Descourt Patrice, Dekker André, De Ruysscher Dirk, Oellers Michel, Lambin Philippe, Pradier Olivier, Visvikis Dimitris, Accurate Automatic Delineation of Heterogeneous Functional Volumes in Positron Emission Tomography for Oncology Applications, 10.1016/j.ijrobp.2009.08.018
  17. Zaidi Habib, Abdoli Mehrsima, Fuentes Carolina Llina, El Naqa Issam M., Comparative methods for PET image segmentation in pharyngolaryngeal squamous cell carcinoma, 10.1007/s00259-011-2053-0
  18. Machulla H.-J., Blocher A., Kuntzsch M., Piert M., Wei R., Grierson J.R., 10.1023/a:1010684101509
  19. Hatt M., Cheze le Rest C., Turzo A., Roux C., Visvikis D., A Fuzzy Locally Adaptive Bayesian Segmentation Approach for Volume Determination in PET, 10.1109/tmi.2008.2012036
  20. Janssens Geert O., Rademakers Saskia E., Terhaard Chris H., Doornaert Patricia A., Bijl Hendrik P., van den Ende Piet, Chin Alim, Marres Henri A., de Bree Remco, van der Kogel Albert J., Hoogsteen Ilse J., Bussink Johannes, Span Paul N., Kaanders Johannes H., Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial, 10.1200/jco.2011.35.9315
  21. Troost E. G.C., Vogel W. V., Merkx M. A.W., Slootweg P. J., Marres H. A.M., Peeters W. J.M., Bussink J., van der Kogel A. J., Oyen W. J.G., Kaanders J. H.A.M., 18F-FLT PET Does Not Discriminate Between Reactive and Metastatic Lymph Nodes in Primary Head and Neck Cancer Patients, 10.2967/jnumed.106.037473
  22. Krak Nanda C., Boellaard R., Hoekstra Otto S., Twisk Jos W. R., Hoekstra Corneline J., Lammertsma Adriaan A., Effects of ROI definition and reconstruction method on quantitative outcome and applicability in a response monitoring trial, 10.1007/s00259-004-1566-1
  23. Vriens Dennis, Visser Eric P., de Geus-Oei Lioe-Fee, Oyen Wim J. G., Methodological considerations in quantification of oncological FDG PET studies, 10.1007/s00259-009-1306-7
  24. Werner-Wasik Maria, Nelson Arden D., Choi Walter, Arai Yoshio, Faulhaber Peter F., Kang Patrick, Almeida Fabio D., Xiao Ying, Ohri Nitin, Brockway Kristin D., Piper Jonathan W., Nelson Aaron S., What Is the Best Way to Contour Lung Tumors on PET Scans? Multiobserver Validation of a Gradient-Based Method Using a NSCLC Digital PET Phantom, 10.1016/j.ijrobp.2010.12.055
  25. Wanet Marie, Lee John Aldo, Weynand Birgit, De Bast Marc, Poncelet Alain, Lacroix Valérie, Coche Emmanuel, Grégoire Vincent, Geets Xavier, Gradient-based delineation of the primary GTV on FDG-PET in non-small cell lung cancer: A comparison with threshold-based approaches, CT and surgical specimens, 10.1016/j.radonc.2010.10.006
  26. Cheebsumon Patsuree, Boellaard Ronald, de Ruysscher Dirk, van Elmpt Wouter, van Baardwijk Angela, Yaqub Maqsood, Hoekstra Otto S, Comans Emile FI, Lammertsma Adriaan A, van Velden Floris HP, Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology, 10.1186/2191-219x-2-56
  27. Liao Shengri, Penney Bill C., Wroblewski Kristen, Zhang Hao, Simon Cassie A., Kampalath Rony, Shih Ming-Chi, Shimada Naoko, Chen Sheng, Salgia Ravi, Appelbaum Daniel E., Suzuki Kenji, Chen Chin-Tu, Pu Yonglin, Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer, 10.1007/s00259-011-1934-6
  28. Dibble E. H., Lara Alvarez A. C., Truong M.-T., Mercier G., Cook E. F., Subramaniam R. M., 18F-FDG Metabolic Tumor Volume and Total Glycolytic Activity of Oral Cavity and Oropharyngeal Squamous Cell Cancer: Adding Value to Clinical Staging, 10.2967/jnumed.111.099531
  29. Hatt Mathieu, Cheze Le Rest Catherine, Albarghach Nidal, Pradier Olivier, Visvikis Dimitris, PET functional volume delineation: a robustness and repeatability study, 10.1007/s00259-010-1688-6
  30. Hatt M., Cheze-Le Rest C., Aboagye E. O., Kenny L. M., Rosso L., Turkheimer F. E., Albarghach N. M., Metges J.-P., Pradier O., Visvikis D., Reproducibility of 18F-FDG and 3'-Deoxy-3'-18F-Fluorothymidine PET Tumor Volume Measurements, 10.2967/jnumed.110.078501
  31. Heijmen Linda, de Geus-Oei Lioe-Fee, de Wilt Johannes H. W., Visvikis Dimitris, Hatt Mathieu, Visser Eric P., Bussink Johan, Punt Cornelis J. A., Oyen Wim J. G., van Laarhoven Hanneke W. M., Reproducibility of functional volume and activity concentration in 18F-FDG PET/CT of liver metastases in colorectal cancer, 10.1007/s00259-012-2233-6
  32. Hatt M., Groheux D., Martineau A., Espie M., Hindie E., Giacchetti S., de Roquancourt A., Visvikis D., Cheze-Le Rest C., Comparison Between 18F-FDG PET Image-Derived Indices for Early Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer, 10.2967/jnumed.112.108837
  33. Hatt Mathieu, van Stiphout Ruud, le Pogam Adrien, Lammering Guido, Visvikis Dimitris, Lambin Philippe, Early prediction of pathological response in locally advanced rectal cancer based on sequential18F-FDG PET, 10.3109/0284186x.2012.702923
  34. Hatt Mathieu, Visvikis Dimitris, Albarghach Nidal M., Tixier Florent, Pradier Olivier, Cheze-le Rest Catherine, Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology, 10.1007/s00259-011-1755-7
  35. Troost E. G. C., Bussink J., Slootweg P. J., Peeters W. J. M., Merkx M. A. W., van der Kogel A. J., Oyen W. J. G., Kaanders J. H. A. M., Histopathologic Validation of 3'-Deoxy-3'-18F-Fluorothymidine PET in Squamous Cell Carcinoma of the Oral Cavity, 10.2967/jnumed.109.071910
Bibliographic reference Arens, Anne I. J. ; Troost, Esther G. C. ; Hoeben, Bianca A. W. ; Grootjans, Willem ; Lee, John Aldo ; et. al. Semiautomatic methods for segmentation of the proliferative tumour volume on sequential FLT PET/CT images in head and neck carcinomas and their relation to clinical outcome. In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, no. 5, p. 915-924 (2014)
Permanent URL http://hdl.handle.net/2078.1/156138