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Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins

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Gordon-Alonso, Monica [UCL] Demotte, Nathalie [UCL] van der Bruggen, Pierre [UCL]

Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TILs ex vivo with galectin antagonists for a few hours boosts their functions. Several galectin antagonists are currently available for clinical trials.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "OncoImmunology" - Vol. 3, no.5, p. e28783 (2014)
Peer reviewed yes
Publisher Landes Bioscience (Austin)
issn 2162-4011
e-issn 2162-402X
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
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Bibliographic reference Gordon-Alonso, Monica ; Demotte, Nathalie ; van der Bruggen, Pierre. Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins. In: OncoImmunology, Vol. 3, no.5, p. e28783 (2014)
Permanent URL http://hdl.handle.net/2078.1/152964