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The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review.

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DEVALET, Bérangère [UCL] Mullier, François [UCL] Chatelain, Bernard [UCL] Dogné, Jean-Michel Chatelain, Christian [UCL]

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired disorder of the haematopoietic stem cell that makes blood cells more sensitive to the action of complement. PNH patients experience an increased risk of arterial and venous thrombosis - major causes of death due to this disease. Though many potential interlaced mechanisms are suspected, extracellular vesicles (EVs) of various origins may play a central role. The processes possibly involved are haemolysis, platelet activation, injured endothelial cells and monocyte activation. The impact of transfusion should be evaluated. A better understanding of the mechanisms involved may help to propose guidelines for the prophylaxis and treatment of thrombosis in PNH. In this paper, we propose an updated review of the pathophysiology of the underlying mechanisms of thrombosis associated with PNH, with specific focus on the prominent role of EVs.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Journal of Extracellular Vesicles" - Vol. 3 (2014) (2014)
Peer reviewed yes
issn 2001-3078
e-issn 2001-3078
Affiliations UCL - (MGD) Service d'hématologie
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Laboratoire de biologie clinique
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies
Links
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Bibliographic reference DEVALET, Bérangère ; Mullier, François ; Chatelain, Bernard ; Dogné, Jean-Michel ; Chatelain, Christian. The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review.. In: Journal of Extracellular Vesicles, Vol. 3 (2014) (2014)
Permanent URL http://hdl.handle.net/2078/145246