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Assessing malaria transmission in a low endemicity area of north-western Peru

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Rosas Aguirre, Angel [UCL] Llanos-Cuentas, Alejandro Speybroeck, Niko [UCL] Cook, Jackie Contreras-Mancilla, Juan Erhart, Annette

BACKGROUND: Where malaria endemicity is low, control programmes need increasingly sensitive tools for monitoring malaria transmission intensity (MTI) and to better define health priorities. A cross-sectional survey was conducted in a low endemicity area of the Peruvian north-western coast to assess the MTI using both molecular and serological tools. METHODS: Epidemiological, parasitological and serological data were collected from 2,667 individuals in three settlements of Bellavista district, in May 2010. Parasite infection was detected using microscopy and polymerase chain reaction (PCR). Antibodies to Plasmodium vivax merozoite surface protein-119 (PvMSP1₁₉) and to Plasmodium falciparum glutamate-rich protein (PfGLURP) were detected by ELISA. Risk factors for exposure to malaria (seropositivity) were assessed by multivariate survey logistic regression models. Age-specific antibody prevalence of both P. falciparum and P. vivax were analysed using a previously published catalytic conversion model based on maximum likelihood for generating seroconversion rates (SCR). RESULTS: The overall parasite prevalence by microscopy and PCR were extremely low: 0.3 and 0.9%, respectively for P. vivax, and 0 and 0.04%, respectively for P. falciparum, while seroprevalence was much higher, 13.6% for P. vivax and 9.8% for P. falciparum. Settlement, age and occupation as moto-taxi driver during previous year were significantly associated with P. falciparum exposure, while age and distance to the water drain were associated with P. vivax exposure. Likelihood ratio tests supported age seroprevalence curves with two SCR for both P. vivax and P. falciparum indicating significant changes in the MTI over time. The SCR for PfGLURP was 19-fold lower after 2002 as compared to before (λ1 = 0.022 versus λ2 = 0.431), and the SCR for PvMSP1₁₉ was four-fold higher after 2006 as compared to before (λ1 = 0.024 versus λ2 = 0.006). CONCLUSION: Combining molecular and serological tools considerably enhanced the capacity of detecting current and past exposure to malaria infections and related risks factors in this very low endemicity area. This allowed for an improved characterization of the current human reservoir of infections, largely hidden and heterogeneous, as well as providing insights into recent changes in species specific MTIs. This approach will be of key importance for evaluating and monitoring future malaria elimination strategies.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2013
Language Anglais
Journal information "Malaria Journal" - Vol. 12, p. 339 [1-13] (2013)
Peer reviewed yes
Publisher BioMed Central Ltd. ((United Kingdom) London)
e-issn 1475-2875
Publication status Publié
Affiliation UCL - SSS/IRSS - Institut de recherche santé et société
Links
  1. Roberts Donald R., Laughlin Larry L., Hsheih Paul, Legters Llewellyn J., DDT, Global Strategies, and a Malaria Control Crisis in South America, 10.3201/eid0303.970305
  2. Gagnon Alexandre S., Smoyer-Tomic Karen E., Bush Andrew B., The El Niño Southern Oscillation and malaria epidemics in South America, 10.1007/s00484-001-0119-6
  3. Williams Holly, Vincent-Mark Arlene, Herrera Yenni, Chang O Jaime, A retrospective analysis of the change in anti-malarial treatment policy: Peru, 10.1186/1475-2875-8-85
  4. Flores Walter, Chang Jaime, Barillas Edgar, Rapid assessment of the performance of malaria control strategies implemented by countries in the Amazon subregion using adequacy criteria: case study, 10.1186/1475-2875-10-379
  5. Rosas-Aguirre Angel, Guzmán-Guzmán Mitchel, Moreno-Gutierrez Diamantina, Rodriguez-Ferrucci Hugo, Vargas-Pacherrez Daniel, Acuña-González Ysabel, Posesión, retención y uso de mosquiteros tratados con insecticidas de larga duración luego de un año de su distribución en Loreto, Perú, 10.1590/s1726-46342011000200009
  6. Hay Simon I, Smith David L, Snow Robert W, Measuring malaria endemicity from intense to interrupted transmission, 10.1016/s1473-3099(08)70069-0
  7. Greenwood Brian M., Control to elimination: implications for malaria research, 10.1016/j.pt.2008.07.002
  8. Byass Peter, Making sense of long-term changes in malaria, 10.1016/s0140-6736(08)61631-1
  9. Elissa N., Migot-Nabias F., Luty A., Renaut A., Touré F., Vaillant M., Lawoko M., Yangari P., Mayombo J., Lekoulou F., Tshipamba P., Moukagni R., Millet P., Deloron P., Relationship between entomological inoculation rate, Plasmodium falciparum prevalence rate, and incidence of malaria attack in rural Gabon, 10.1016/s0001-706x(02)00266-8
  10. Kelly-Hope Louise A, McKenzie F Ellis, The multiplicity of malaria transmission: a review of entomological inoculation rate measurements and methods across sub-Saharan Africa, 10.1186/1475-2875-8-19
  11. Steenkeste Nicolas, Rogers William O, Okell Lucy, Jeanne Isabelle, Incardona Sandra, Duval Linda, Chy Sophy, Hewitt Sean, Chou Monidarin, Socheat Duong, Babin François-Xavier, Ariey Frédéric, Rogier Christophe, Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination, 10.1186/1475-2875-9-108
  12. Johnston S. P., Pieniazek N. J., Xayavong M. V., Slemenda S. B., Wilkins P. P., da Silva A. J., PCR as a Confirmatory Technique for Laboratory Diagnosis of Malaria, 10.1128/jcm.44.3.1087-1089.2006
  13. Taylor S. M., Juliano J. J., Trottman P. A., Griffin J. B., Landis S. H., Kitsa P., Tshefu A. K., Meshnick S. R., High-Throughput Pooling and Real-Time PCR-Based Strategy for Malaria Detection, 10.1128/jcm.01800-09
  14. Corran Patrick, Coleman Paul, Riley Eleanor, Drakeley Chris, Serology: a robust indicator of malaria transmission intensity?, 10.1016/j.pt.2007.08.023
  15. Williams Geoffrey S, Mweya Clement, Stewart Laveta, Mtove George, Reyburn Hugh, Cook Jackie, Corran Patrick H, Riley Eleanor M, Drakeley Chris J, Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity, 10.1186/1475-2875-8-168
  16. Drakeley C. J., Corran P. H., Coleman P. G., Tongren J. E., McDonald S. L. R., Carneiro I., Malima R., Lusingu J., Manjurano A., Nkya W. M. M., Lemnge M. M., Cox J., Reyburn H., Riley E. M., Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure, 10.1073/pnas.0408725102
  17. Bousema Teun, Youssef Randa M., Cook Jackie, Cox Jonathan, Alegana Victor A., Amran Jamal, Noor Abdisalan M., Snow Robert W., Drakeley Chris, Serologic Markers for Detecting Malaria in Areas of Low Endemicity, Somalia, 2008, 10.3201/eid1603.090732
  18. Stewart Laveta, Gosling Roly, Griffin Jamie, Gesase Samwel, Campo Joseph, Hashim Ramadan, Masika Paul, Mosha Jacklin, Bousema Teun, Shekalaghe Seif, Cook Jackie, Corran Patrick, Ghani Azra, Riley Eleanor M., Drakeley Chris, Rapid Assessment of Malaria Transmission Using Age-Specific Sero-Conversion Rates, 10.1371/journal.pone.0006083
  19. Cook Jackie, Kleinschmidt Immo, Schwabe Christopher, Nseng Gloria, Bousema Teun, Corran Patrick H., Riley Eleanor M., Drakeley Chris J., Serological Markers Suggest Heterogeneity of Effectiveness of Malaria Control Interventions on Bioko Island, Equatorial Guinea, 10.1371/journal.pone.0025137
  20. Guthmann J.-P., Hall A.J., Jaffar S., Palacios A., Lines J., Llanos-Cuentas A., Environmental risk factors for clinical malaria: a case-control study in the Grau region of Peru, 10.1016/s0035-9203(01)90084-7
  21. Cook Jackie, Speybroeck Nico, Sochantha Tho, Somony Heng, Sokny Mao, Claes Filip, Lemmens Kristel, Theison Michael, Soares Irene S, D'Alessandro Umberto, Coosemans Marc, Erhart Annette, Sero-epidemiological evaluation of changes in Plasmodium falciparum and Plasmodium vivax transmission patterns over the rainy season in Cambodia, 10.1186/1475-2875-11-86
  22. Rodrigues Maria Helena C, Cunha Maristela G, Machado Ricardo LD, Ferreira Orlando C, Rodrigues Mauricio M, Soares Irene S, 10.1186/1475-2875-2-39
  23. Corran Patrick H, Cook Jackie, Lynch Caroline, Leendertse Heleen, Manjurano Alphaxard, Griffin Jamie, Cox Jonathan, Abeku Tarekegn, Bousema Teun, Ghani Azra C, Drakeley Chris, Riley Eleanor, Dried blood spots as a source of anti-malarial antibodies for epidemiological studies, 10.1186/1475-2875-7-195
  24. Cook Jackie, Reid Heidi, Iavro Jennifer, Kuwahata Melissa, Taleo George, Clements Archie, McCarthy James, Vallely Andrew, Drakeley Chris, Using serological measures to monitor changes in malaria transmission in Vanuatu, 10.1186/1475-2875-9-169
  25. Guthmann J. P., Llanos-Cuentas A., Palacios A., Hall A. J., Environmental factors as determinants of malaria risk. A descriptive study on the northern coast of Peru, 10.1046/j.1365-3156.2002.00883.x
  26. Branch OraLee, Casapia W Martin, Gamboa Dionicia V, Hernandez Jean N, Alava Freddy F, Roncal Norma, Alvarez Eugenia, Perez Enrique J, Gotuzzo Eduardo, 10.1186/1475-2875-4-27
  27. da Silva-Nunes Mônica, Moreno Marta, Conn Jan E., Gamboa Dionicia, Abeles Shira, Vinetz Joseph M., Ferreira Marcelo U., Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies, 10.1016/j.actatropica.2011.10.001
  28. Bousema Teun, Drakeley Chris, Gesase Samwel, Hashim Ramadhan, Magesa Stephen, Mosha Frank, Otieno Silas, Carneiro Ilona, Cox Jonathan, Msuya Eliapendavyo, Kleinschmidt Immo, Maxwell Caroline, Greenwood Brian, Riley Eleanor, Sauerwein Robert, Chandramohan Daniel, Gosling Roly, Identification of Hot Spots of Malaria Transmission for Targeted Malaria Control, 10.1086/652456
  29. Águas Ricardo, White Lisa J., Snow Robert W., Gomes M. Gabriela M., Prospects for Malaria Eradication in Sub-Saharan Africa, 10.1371/journal.pone.0001767
  30. Culleton Richard, Ndounga Mathieu, Zeyrek Fadile Yildiz, Coban Cevayir, Casimiro Prisca Nadine, Takeo Satoru, Tsuboi Takafumi, Yadava Anjali, Carter Richard, Tanabe Kazuyuki, Evidence for the Transmission ofPlasmodium vivaxin the Republic of the Congo, West Central Africa, 10.1086/644510
  31. Mutapi F, Roussilhon C, Mduluza T, Druilhe P, Anti-malaria humoral responses in children exposed to Plasmodium falciparum and Schistosoma haematobium, 10.1590/s0074-02762007005000046
  32. Chuquiyauri Raul, Paredes Maribel, Peñataro Pablo, Torres Sonia, Marin Silvia, Tenorio Alexander, Brouwer Kimberly C., Abeles Shira, Llanos-Cuentas Alejandro, Gilman Robert H., Kosek Margaret, Vinetz Joseph M., Socio-demographics and the development of malaria elimination strategies in the low transmission setting, 10.1016/j.actatropica.2011.11.003
  33. Stricker Karin de, Vuust Jens, Jepsen Søren, Oeuvray Claude, Theisen Michael, Conservation and heterogeneity of the glutamate-rich protein (GLURP) among field isolates and laboratory lines of Plasmodium falciparum, 10.1016/s0166-6851(00)00304-2
  34. Speybroeck Niko, Praet Nicolas, Claes Filip, Van Hong Nguyen, Torres Kathy, Mao Sokny, Van den Eede Peter, Thi Thinh Ta, Gamboa Dioni, Sochantha Tho, Thang Ngo Duc, Coosemans Marc, Büscher Philippe, D'Alessandro Umberto, Berkvens Dirk, Erhart Annette, True versus Apparent Malaria Infection Prevalence: The Contribution of a Bayesian Approach, 10.1371/journal.pone.0016705
Bibliographic reference Rosas Aguirre, Angel ; Llanos-Cuentas, Alejandro ; Speybroeck, Niko ; Cook, Jackie ; Contreras-Mancilla, Juan ; et. al. Assessing malaria transmission in a low endemicity area of north-western Peru. In: Malaria Journal, Vol. 12, p. 339 [1-13] (2013)
Permanent URL http://hdl.handle.net/2078.1/141768