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Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy

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Bourdeaux, Christophe [UCL] Lurquin, Christophe [UCL] Jacquemart, Isabelle [UCL] Lethé, Bernard [UCL] Brasseur, Francis [UCL] van Baren, Nicolas [UCL] Baurain, Jean-François [UCL] Van Snick, Jacques [UCL] Uyttenhove, Catherine [UCL] Boon, Thierry [UCL]

Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We show that local immunostimulation performed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes rejection. We feel that this approach should be tested in tumor-bearing human patients in combination with antitumor vaccination. Relief of intratumor immunosuppression may increase considerably the fraction of patients who respond to vaccination directed against tumor antigens recognized by T cells.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Proceedings of the National academy of sciences of the United States of America" - Vol. 111, no.9, p. 3502-3507 (2014)
Peer reviewed yes
Publisher National academy of sciences ((United States) Washington, DC)
issn 0027-8424
e-issn 1091-6490
Publication status Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Unité d'oncologie médicale
UCL - (SLuc) Centre du cancer
Links
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Bibliographic reference Bourdeaux, Christophe ; Lurquin, Christophe ; Jacquemart, Isabelle ; Lethé, Bernard ; Brasseur, Francis ; et. al. Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy. In: Proceedings of the National academy of sciences of the United States of America, Vol. 111, no.9, p. 3502-3507 (2014)
Permanent URL http://hdl.handle.net/2078.1/141470