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Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.

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Hendrickx, Aurélie [UCL] Pierrot, Nathalie [UCL] Tasiaux, Bernadette [UCL] Schakman, Olivier [UCL] Brion, Jean-Pierre [Laboratory of Histology and Neuropathology, Université libre de Bruxelles, Brussels, Belgium] Kienlen-Campard, Pascal [UCL] De Smet, Charles [UCL] Octave, Jean-Noël [UCL]

Following transcriptome comparison of primary cultures isolated from brain of mice expressing or not the amyloid precursor protein APP, we found transcription of the EGR-1 gene to be regulated by APP. In primary cultures of cortical neurons, APP significantly down regulated EGR-1 expression at both mRNA and protein levels in a γ-secretase independent manner. The intracellular domain of APP did not interact with EGR-1 gene promoter, but enrichment of acetylated histone H4 at the EGR-1 promoter region was measured in APP-/- neurons, as well as in brain of APP-/- mice, in which increase in EGR-1 expression was also measured. These results argue for an important function of APP in the epigenetic regulation of EGR-1 gene transcription both in vitro and in vivo. In APP-/- mice, constitutive overexpression of EGR-1 in brain impaired epigenetic induction of this early transcriptional regulator during exposure to novelty. Altogether, these results indicate an important function of APP in the epigenetic regulation of the transcription of EGR-1, known to be important for memory formation.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2013
Language Anglais
Journal information "PloS one" - Vol. 8, no. 9, p. e74305 (2013)
Peer reviewed yes
e-issn 1932-6203
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
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Bibliographic reference Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Brion, Jean-Pierre ; et. al. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.. In: PloS one, Vol. 8, no. 9, p. e74305 (2013)
Permanent URL http://hdl.handle.net/2078.1/140776