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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.

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Coulie, Pierre G. [UCL] Van den Eynde, Benoît [UCL] van der Bruggen, Pierre [UCL] Boon-Falleur, Thierry [UCL]

In this Timeline, we describe the characteristics of tumour antigens that are recognized by spontaneous T cell responses in cancer patients and the paths that led to their identification. We explain on what genetic basis most, but not all, of these antigens are tumour specific: that is, present on tumour cells but not on normal cells. We also discuss how strategies that target these tumour-specific antigens can lead either to tumour-specific or to crossreactive T cell responses, which is an issue that has important safety implications in immunotherapy. These safety issues are even more of a concern for strategies targeting antigens that are not known to induce spontaneous T cell responses in patients.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Nature Reviews. Cancer" - Vol. 14, no.2, p. 135-146 (2014)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1474-175X
e-issn 1474-1768
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
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Permanent URL http://hdl.handle.net/2078.1/139932