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Treatment of cytomegalovirus pneumonitis with ganciclovir in renal transplantation.

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Stoffel, M. [UCL] Pirson, Yves [UCL] Squifflet, Jean-Paul [UCL] Lamy, M. [UCL] Gianello, Pierre [UCL] Alexandre, Guy P. [UCL]

Ganciclovir, also called DHPG, was administered intravenously to eight renal transplant recipients with life-threatening cytomegalovirus (CMV) pneumonitis. One patient died of pulmonary failure; a favorable clinical response was observed in the seven others. In one patient, CMV pneumonitis recurred but responded well to a second course of the drug. At no time was the immunosuppressive regimen completely stopped in the seven surviving patients. Six of them maintained a good renal function 1-11 months after treatment with ganciclovir. No toxic effect was detected during therapy. We conclude that ganciclovir appears to be a promising and effective treatment for CMV pneumonitis after renal transplantation.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès libre
Publication date 1988
Journal information "Transplant international : official journal of the European Society for Organ Transplantation" - Vol. 1, no. 4, p. 181-5 (1988)
Peer reviewed yes
issn 0934-0874
Publication status Publié
Affiliations UCL - MD/CHIR - Département de chirurgie
UCL - (SLuc) Service de chirurgie et transplantation abdominale
UCL - (SLuc) Service de néphrologie
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de microbiologie
MESH Subject Acyclovir - adverse effects - analogs & derivatives - therapeutic use ; Adolescent ; Adult ; Antiviral Agents - adverse effects - therapeutic use ; Cytomegalovirus Infections - complications - drug therapy ; Female ; Ganciclovir ; Humans ; Immunosuppressive Agents - therapeutic use ; Kidney Transplantation ; Male ; Middle Aged ; Pneumonia, Viral - complications - drug therapy
Links
  1. , Treatment of Serious Cytomegalovirus Infections with 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine in Patients with AIDS and Other Immunodeficiencies, 10.1056/nejm198603273141301
  2. Creasy TerryS., Flower AudreyJ.E., Veitch PeterS., LIFE-THREATENING CYTOMEGALOVIRUS INFECTION TREATED WITH DIHYDROPROPOXYMETHYLGUANINE, 10.1016/s0140-6736(86)91742-3
  3. Erice A., Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts, 10.1001/jama.257.22.3082
  4. Grundy JaneE., Shanley JohnD., Griffiths PaulD., IS CYTOMEGALOVIRUS INTERSTITIAL PNEUMONITIS IN TRANSPLANT RECIPIENTS AN IMMUNOPATHOLOGICAL CONDITION?, 10.1016/s0140-6736(87)92560-8
  5. Hecht D. W., Snydman D. R., Crumpacker C. S., Werner B. G., Heinze-Lacey B., , Ganciclovir for Treatment of Renal Transplant-Associated Primary Cytomegalovirus Pneumonia, 10.1093/infdis/157.1.187
  6. Marker S. C., A trial of vidarabine for cytomegalovirus infection in renal transplant patients, 10.1001/archinte.140.11.1441
  7. PETERSON PHILLIP K., BALFOUR HENRY H., MARKER STEPHEN C., FRYD DAVID S., HOWARD RICHARD J., SIMMONS RICHARD L., Cytomegalovirus Disease in Renal Allograft Recipients : A Prospective Study of the Clinical Features, Risk Factors and Impact on Renal Transplantation, 10.1097/00005792-198007000-00004
  8. Snydman David R., Werner Barbara G., Heinze-Lacey Beverly, Berardi Victor P., Tilney Nicholas L., Kirkman Robert L., Milford Edgar L., Cho Sang I., Bush Harry L., Levey Andrew S., Strom Terry B., Carpenter Charles B., Levey Raphael H., Harmon William E., Zimmerman Clarence E., Shapiro Michael E., Steinman Theodore, LoGerfo Frank, Idelson Beldon, Schröter Gerhard P.J., Levin Myron J., McIver James, Leszczynski Jeanne, Grady George F., Use of Cytomegalovirus Immune Globulin to Prevent Cytomegalovirus Disease in Renal-Transplant Recipients, 10.1056/nejm198710223171703
  9. TYMS A, BWB759U, AN ANALOGUE OF ACYCLOVIR, INHIBITS HUMAN CYTOMEGALOVIRUS IN VITRO, 10.1016/s0140-6736(84)90677-9
  10. Wade James C., Hintz Marie, McGuffin Robert W., Springmeyer Steven C., Connor James D., Meyers Joel D., Treatment of cytomegalovirus pneumonia with high-dose acyclovir, 10.1016/0002-9343(82)90100-0
Bibliographic reference Stoffel, M. ; Pirson, Yves ; Squifflet, Jean-Paul ; Lamy, M. ; Gianello, Pierre ; et. al. Treatment of cytomegalovirus pneumonitis with ganciclovir in renal transplantation.. In: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 1, no. 4, p. 181-5 (1988)
Permanent URL http://hdl.handle.net/2078.1/13951