User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

The efficacy and safety of chronic oral administration of xamoterol to patients with severe heart failure treated with ACE inhibitors.

Primary tabs

download
  • Open access
  • PDF
  • -1.00 B
Pouleur, H. Hanet, Claude [UCL] Rousseau, Michel [UCL]

Xamoterol 200 mg twice daily was given for 2 months to nine patients with severe heart failure already being treated with angiotensin converting enzyme (ACE) inhibitors. Left ventricular end-diastolic pressure fell from 28 to 13 mmHg and end-systolic volume fell from 115 to 106 ml m-2; indices of contractility improved and ejection fraction rose from 33 to 38%. The time constant of ventricular relaxation, T1, improved from 62 to 44 ms. Exercise tolerance improved. Thus, in this group of patients with severe heart failure, xamoterol produced benefits in systolic and diastolic function. There were no adverse effects.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès libre
Publication date 1989
Journal information "British journal of clinical pharmacology" - Vol. 28 Suppl 1, p. 82S-83S (1989)
Peer reviewed yes
issn 0306-5251
Publication status Publié
Affiliation UCL
MESH Subject Adrenergic beta-Agonists - administration & dosage - adverse effects - therapeutic use ; Aged ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Exercise ; Female ; Heart Failure - drug therapy - physiopathology ; Hemodynamics - drug effects ; Humans ; Male ; Middle Aged ; Propanolamines - administration & dosage - adverse effects - therapeutic use ; Xamoterol
Links
Bibliographic reference Pouleur, H. ; Hanet, Claude ; Rousseau, Michel. The efficacy and safety of chronic oral administration of xamoterol to patients with severe heart failure treated with ACE inhibitors.. In: British journal of clinical pharmacology, Vol. 28 Suppl 1, p. 82S-83S (1989)
Permanent URL http://hdl.handle.net/2078.1/13938