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Contrasting effects of single doses of pindolol and xamoterol on left ventricular diastolic function.

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Rousseau, Michel [UCL] Pouleur, H. Debaisieux, J C van Eyll, Christian [UCL] Charlier, André [UCL]

Impaired left ventricular diastolic dysfunction is common in patients with ischaemic heart failure. The beta 1-adrenoceptor partial agonist xamoterol was compared with pindolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic activity, in a haemodynamic study in 17 patients with ischaemic heart disease. Pindolol caused left ventricular end-diastolic pressure, wall stress and T1 to rise, whereas xamoterol produced improvements in all three parameters. These results suggest that xamoterol may be of greater benefit to patients in heart failure.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès libre
Publication date 1989
Journal information "British journal of clinical pharmacology" - Vol. 28 Suppl 1, p. 84S-85S (1989)
Peer reviewed yes
issn 0306-5251
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Adrenergic beta-Agonists - pharmacology ; Blood Pressure - drug effects ; Coronary Disease - physiopathology ; Diastole ; Female ; Heart - drug effects ; Heart Rate - drug effects ; Humans ; Male ; Pindolol - pharmacology ; Propanolamines - pharmacology ; Xamoterol
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Bibliographic reference Rousseau, Michel ; Pouleur, H. ; Debaisieux, J C ; van Eyll, Christian ; Charlier, André. Contrasting effects of single doses of pindolol and xamoterol on left ventricular diastolic function.. In: British journal of clinical pharmacology, Vol. 28 Suppl 1, p. 84S-85S (1989)
Permanent URL http://hdl.handle.net/2078.1/13937