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Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.

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Gaussin, V. Baquet, A. Hue, Louis [UCL]

The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.

Document type Article de périodique (Journal article) – In Vitro, Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 1992
Journal information "The Biochemical journal" - Vol. 287 ( Pt 1), p. 17-20 (1992)
Peer reviewed yes
issn 0264-6021
Publication status Publié
Affiliation UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Animals ; Cell Size - drug effects ; Cyclic AMP - metabolism ; Glucagon - pharmacology ; Gluconeogenesis - drug effects ; Insulin - pharmacology ; Liver - cytology - metabolism ; Liver Glycogen - metabolism ; Male ; Phosphorylases - metabolism ; Pyruvate Kinase - metabolism ; Rats ; Rats, Wistar ; Water-Electrolyte Balance - drug effects
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Bibliographic reference Gaussin, V. ; Baquet, A. ; Hue, Louis. Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.. In: The Biochemical journal, Vol. 287 ( Pt 1), p. 17-20 (1992)
Permanent URL http://hdl.handle.net/2078.1/13625