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Ternary and quaternary phase diagrams: Key tools for chiral resolution through solution cocrystallization

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Springuel, Géraldine [UCL] Collard, Laurent [UCL] Leyssens, Tom [UCL]

The goal of this contribution is to guide the reader through the construction and the understanding of quaternary phase diagrams in the pursuit of optimal conditions for a chiral resolution through cocrystallization in solution. The overall description will be illustrated by experimental results on a system involving RS-2-(2-oxopyrrolidin-1-yl) butanamide as chiral API to be separated, and S-mandelic acid as chiral coformer. © 2013 The Royal Society of Chemistry.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "CrystEngComm" - Vol. 15, no.39, p. 7951-7958 (2013)
Peer reviewed yes
issn 1466-8033
Publication status Publié
Affiliation UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity
Links
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Bibliographic reference Springuel, Géraldine ; Collard, Laurent ; Leyssens, Tom. Ternary and quaternary phase diagrams: Key tools for chiral resolution through solution cocrystallization. In: CrystEngComm, Vol. 15, no.39, p. 7951-7958 (2013)
Permanent URL http://hdl.handle.net/2078.1/134627