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Scintigraphic evaluation of the haemopoietic bone marrow using a 99mTc-anti-granulocyte antibody: a validation study with 52Fe.

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Jamar, François [UCL] Field, C Leners, N. Ferrant, Augustin [UCL]

To specify the validity of bone marrow scanning using a monoclonal anti-granulocyte antibody labelled with 99mTc (BW 250/183) for the functional assessment of haemopoiesis, we compared this method with 52Fe scan in 16 patients with haematological disorders. The examinations were performed using a rectilinear whole-body scanner and the distribution of the two tracers was assessed visually and quantitatively in anatomical bone marrow segments, the spleen and liver. Qualitative comparison showed concordance in the bone marrow distribution of the two tracers in 83% of the segments. Discrepancies were found in six patients with hypoplastic or aplastic marrow. The spleen was visualized in all cases with the 99mTc-Moab, including nine patients without splenic haemopoiesis (i.e. without spleen uptake of 52Fe). The uptake of the two tracers, quantified in bone marrow segments and the spleen, correlated well (P < 0.001), but not in the liver (NS). The correlation between the uptake values for each patient was excellent, except in cases of aplastic bone marrow. In conclusion, bone marrow scanning using a 99mTc labelled anti-granulocyte monoclonal antibody enables functional evaluation of the distribution of haemopoiesis. Limitations include the evaluation of bone marrow aplasia and identification of splenic haemopoiesis, for which 52Fe remains the tracer of choice.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Publication date 1995
Journal information "British journal of haematology" - Vol. 90, no. 1, p. 22-30 (1995)
Peer reviewed yes
issn 0007-1048
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
MESH Subject Adolescent ; Adult ; Aged ; Anemia, Aplastic - radionuclide imaging ; Antibodies, Monoclonal - diagnostic use ; Bone Marrow - radionuclide imaging ; Female ; Granulocytes - immunology ; Hematologic Diseases - radionuclide imaging ; Hematopoiesis ; Hodgkin Disease - radionuclide imaging ; Humans ; Iron Radioisotopes - diagnostic use ; Leukemia, Hairy Cell - radionuclide imaging ; Liver - radionuclide imaging ; Male ; Middle Aged ; Spleen - radionuclide imaging ; Technetium - diagnostic use
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Bibliographic reference Jamar, François ; Field, C ; Leners, N. ; Ferrant, Augustin. Scintigraphic evaluation of the haemopoietic bone marrow using a 99mTc-anti-granulocyte antibody: a validation study with 52Fe.. In: British journal of haematology, Vol. 90, no. 1, p. 22-30 (1995)
Permanent URL http://hdl.handle.net/2078.1/13357