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Noninvasive measurement of the pH inside the gut by using pH-sensitive nitroxides. An in vivo EPR study

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Gallez, Bernard [UCL] Mäder, Karsten Swartz, Harold M.

The use of pH-sensitive probes permits the measurement of the proton activity in biological systems by EPR spectroscopy. To illustrate the potential of this technique for in vivo purposes, the authors took advantage of the oral administration of nitroxides to monitor the pH value inside the stomach of mice after administration of different antacidics. The results indicate that EPR can be a valuable tool to characterize the pH in vivo in a continuous and noninvasive way.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1996
Journal information "Magnetic Resonance in Medicine" - Vol. 36, no. 5, p. 694-697 (1996)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 0740-3194
e-issn 1522-2594
Publication status Publié
Affiliations UCL - MD/FARM - Ecole de pharmacie
UCL - (SLuc) Service de médecine nucléaire
MESH Subject Animals ; Digestive System - metabolism ; Electron Spin Resonance Spectroscopy ; Free Radicals ; Hydrogen-Ion Concentration ; Male ; Mice ; Nitrogen Oxides - diagnostic use
Keywords In vivo EPR ; Nitroxide ; pH ; Stomach
Links
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Bibliographic reference Gallez, Bernard ; Mäder, Karsten ; Swartz, Harold M.. Noninvasive measurement of the pH inside the gut by using pH-sensitive nitroxides. An in vivo EPR study. In: Magnetic Resonance in Medicine, Vol. 36, no. 5, p. 694-697 (1996)
Permanent URL http://hdl.handle.net/2078.1/13224