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Tissue inhibitors of matrix metalloproteinases in cancer.

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Blavier, L Henriet, Patrick [UCL] Imren, S Declerck, Y A

Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival. The role of these inhibitors in cancer has been the subject of extensive investigations that have examined their biological activity in tumor growth, invasion, metastasis and angiogenesis, as well as their potential use in the diagnosis and treatment of human cancer.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1999
Language Anglais
Journal information "Annals of the New York Academy of Sciences" - Vol. 878, no.0, p. 108-19 (1999)
Peer reviewed yes
issn 1749-6632
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Cell Division ; Extracellular Matrix ; Humans ; Metalloendopeptidases ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms ; Neovascularization, Pathologic ; Tissue Inhibitor of Metalloproteinases
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Bibliographic reference Blavier, L ; Henriet, Patrick ; Imren, S ; Declerck, Y A. Tissue inhibitors of matrix metalloproteinases in cancer.. In: Annals of the New York Academy of Sciences, Vol. 878, no.0, p. 108-19 (1999)
Permanent URL http://hdl.handle.net/2078.1/132190