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Generating spinal motor neuron diversity: a long quest for neuronal identity

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Francius, Cédric [UCL] Clotman, Frédéric [UCL]

Understanding how thousands of different neuronal types are generated in the CNS constitutes a major challenge for developmental neurobiologists and is a prerequisite before considering cell or gene therapies of nervous lesions or pathologies. During embryonic development, spinal motor neurons (MNs) segregate into distinct subpopulations that display specific characteristics and properties including molecular identity, migration pattern, allocation to specific motor columns, and innervation of defined target. Because of the facility to correlate these different characteristics, the diversification of spinal MNs has become the model of choice for studying the molecular and cellular mechanisms underlying the generation of multiple neuronal populations in the developing CNS. Therefore, how spinal motor neuron subpopulations are produced during development has been extensively studied during the last two decades. In this review article, we will provide a comprehensive overview of the genetic and molecular mechanisms that contribute to the diversification of spinal MNs.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2014
Language Anglais
Journal information "Cellular and Molecular Life Sciences" - Vol. 71, no. 5, p. 813-829 (2014)
Peer reviewed yes
Publisher Birkhaeuser Verlag AG ((Switzerland) Basel)
issn 1420-682X
e-issn 1420-9071
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Links
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Bibliographic reference Francius, Cédric ; Clotman, Frédéric. Generating spinal motor neuron diversity: a long quest for neuronal identity. In: Cellular and Molecular Life Sciences, Vol. 71, no. 5, p. 813-829 (2014)
Permanent URL http://hdl.handle.net/2078.1/132073