User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Immunological relatedness of the protective mechanisms against tuberculosis and cancer.

Primary tabs

Cocito, Carlo [UCL] Maes, Hubert [UCL]

BACKGROUND: Bacille Calmette-Guérin (BCG), an attenuated strain of tuberculous bacillus, is the source of vaccines providing unclear and variable protection against tuberculosis (TB) and cancer. Thermostable macromolecular antigens (TMAs) are major mycobacterial complexes immunodominant in disease. A60 (TMA complex of BCG) protects mice against TB development, via T lymphocyte (TL)-mediated macrophage (Mphi) activation, halting intracellular mycobacterial replication. In most A60-primed mice, cytolytic TLs and Mphi infiltrate cancer tissue, resulting in 80-100% rejection. Adoptive TL transfer is indispensable for Mphi-dependent tumour cell inactivation via oxygen and nitrogen radicals. Neoplasm development induces immune anergy with depletion ofA60-specific TL and activated Mphi. A60 protects mice against TB and cancer by inducing the synthesis of three lymphokines: interleukin 2 (IL-2), interferon gamma (IFN-gamma) and tumour necrosis factor alpha (TNF-alpha). Tumour cells prevent A60-dependent synthesis of these lymphokines in vivo and in vitro. CONCLUSION: These data provide some clues to immune surveillance and tumour escape mechanisms, as well as to the antituberculous and antineoplastic BCG action.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't, Review
Publication date 1998
Journal information "European journal of clinical investigation" - Vol. 28, no. 1, p. 1-12 (1998)
Peer reviewed yes
issn 0014-2972
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; BCG Vaccine - immunology ; Humans ; Neoplasms - immunology - prevention & control ; Neoplasms, Experimental - immunology - prevention & control ; Tuberculosis - immunology - prevention & control
Links
  1. Colditz G. A., Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature, 10.1001/jama.271.9.698
  2. Fine P. E. M., Bacille Calmette-Guerin Vaccines: A Rough Guide, 10.1093/clinids/20.1.11
  3. Roche Paul W, Triccas James A, Winter Nathalie, BCG vaccination against tuberculosis: past disappointments and future hopes, 10.1016/s0966-842x(00)88986-6
  4. Hersh E M, Gutterman J U, Mavligit G M, BCG as Adjuvant Immunotherapy for Neoplasia, 10.1146/annurev.me.28.020177.002421
  5. Baldwin RW, Advances in Cancer Research, 28, 91 (1978)
  6. Milas L, Advances in Cancer Research, 26, 257 (1978)
  7. 7 MT Lotze, and OJ Finn .Cellular Immunity and Immunotherapy of Cancer. New York: Wiley-Liss, 1990 .
  8. 8 RK Oldam .Principles of Cancer Biotherapy. New York: M. Dekker, 1991 .
  9. 9 VT De Vita, S Hellman, and SA Rosenberg (eds).Biologic Therapy of Cancer. Philadelphia: Lippincott, 1991 .
  10. 10 G Lamoureux, R Turcotte, and V Portellance , eds.BCG in Cancer Immunotherapy. New York: Grune & Stratton, 1976 .
  11. 11 GP Youmans . Pathogenesis of tuberculosis. In: Youmans GP, ed.Tuberculosis. Philadelphia: WB Saunders, 1979 : 317, 326 .
  12. 12 GP Youmans . Tuberculosis. In: Youmans GP, Paterson PY, Sommers HM, eds.The Biological and Clinical Basis of Infectious Diseases. Philadelphia: WB Saunders, 1985 : 348, 367 .
  13. 13 PC Hopewell . Overview of clinical tuberculosis. In: Bloom BR, ed.Tuberculosis. Washington: ASM Press, 1994 : 25, 46 .
  14. 14 TD Daniel . Tuberculosis. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, eds.Harrison's Principles of Internal Medicine, 3rd edn. New York: McGraw-Hill 1994 : 710, 718 .
  15. Lucas SB, British Medical Bulletin, 44, 584 (1988)
  16. Cocito C, Gilot P, Coene M, de Kesel M, Poupart P, Vannuffel P, Paratuberculosis., 10.1128/cmr.7.3.328
  17. Collins FM, Cell Immunology, 1, 253 (1970)
  18. Lefford MJ, Infectious Immunology, 11, 1176 (1975)
  19. Collins FM, American Review of Respiratory Diseases, 125, 42 (1982)
  20. Collins F M, Mycobacterial disease, immunosuppression, and acquired immunodeficiency syndrome., 10.1128/cmr.2.4.360
  21. Crowle AJ, Infection and Immunity, 31, 453 (1981)
  22. Rook GAW, Immunology, 59, 333 (1986)
  23. Beschin A, European Journal of Immunology, 21, 793 (1991)
  24. Hernandez-Pando R, Immunology, 82, 591 (1994)
  25. Surcel HM, Immunology, 81, 171 (1994)
  26. Kaplan Gilla, Cytokine Regulation of Disease Progression in Leprosy and Tuberculosis, 10.1016/s0171-2985(11)80463-8
  27. Rook G.A.W., Hernandez-Pando Rogelio, THE PATHOGENESIS OF TUBERCULOSIS, 10.1146/annurev.micro.50.1.259
  28. Barksdale L, Bacteriological Review, 41, 217 (1977)
  29. Daniel TM, Microbiology Review, 42, 84 (1978)
  30. Lederer E, Molecular and Cellular Biochemistry, 7, 87 (1975)
  31. McNeil M.R., Brennan P.J., Structure, function and biogenesis of the cell envelope of mycobacteria in relation to bacterial physiology, pathogenesis and drug resistance; some thoughts and possibilities arising from recent structural information, 10.1016/0923-2508(91)90120-y
  32. Young DB, Molecular Microbiology, 6, 133 (1992)
  33. Closs O, Scandinavian Journal of Immunology, 12, 249 (1980)
  34. Cocito C, Clinical and Experimental Immunology, 66, 262 (1986)
  35. Fabre I, Scandinavian Journal of Immunology, 24, 591 (1986)
  36. Cocito C, Scandinavian Journal of Immunology, 41, 179 (1995)
  37. Coetsier C, Clinical Diagnostic Laboratory Immunology, 1, 139 (1994)
  38. Hastings R C, Gillis T P, Krahenbuhl J L, Franzblau S G, Leprosy., 10.1128/cmr.1.3.330
  39. Carlucci S, Infection and Immunity, 61, 439 (1993)
  40. Zou Y. L., Zhang J. D., Chen M. H., Shi G. Q., Prignot J., Cocito C., Serological Analysis of Pulmonary and Extrapulmonary Tuberculosis with Enzyme-Linked Immunosorbent Assays for Anti-A60 Immunoglobulins, 10.1093/clinids/19.6.1084
  41. Gilot P, Scandinavian Journal of Immunology, 36, 811 (1992)
  42. Cocito C, Chest, 100, 1687 (1991)
  43. Hubbard RD, Clinical and Experimental Immunology, 88, 129 (1992)
  44. Douvas GS, Infection and Immunity, 50, 1 (1985)
  45. Rook GAW, Immunology, 57, 159 (1986)
  46. Flesch I, Journal of Immunology, 138, 4408 (1987)
  47. Jensen W. A., Rose R. M., Wasserman A. S., Kalb T. H., Anton K., Remold H. G., In Vitro Activation of the Antibacterial Activity of Human Pulmonary Macrophages by Recombinant   Interferon, 10.1093/infdis/155.3.574
  48. Flesch IEA, Infection and Immunity, 56, 1404 (1988)
  49. Murray HW, Journal of Immunology, 138, 2290 (1987)
  50. Belosevic M, FASEB Journal, 46 (1987)
  51. Green SJ, Journal of Immunology, 144, 278 (1990)
  52. Allen C, Immunology, 55, 289 (1985)
  53. Wilson KM, Cell Immunology, 123, 158 (1989)
  54. Haberts JMW, Virchow's Archives A: Pathology and Anatomy, 415, 125 (1989)
  55. Whitworth PW, Cancer Metastases Review, 8, 319 (1989)
  56. Norazmi MN, Immunology, 69, 282 (1990)
  57. 57 H Maes . Prevention of cancer development by the antigen 60 mycobacterial complex and of cancer-promoted inhibition of immune reactions. Brussels: Doctorate thesis, Universite Catholique de Louvain, 1995 : 211, 214 .
  58. Maes H, Scandinavian Journal of Immunology, 41, 53 (1995)
  59. Maes H, Journal of Cancer Research and Clinical Oncology, 122, 296 (1996)
  60. Bloemena E, Cancer Research, 53, 456 (1993)
  61. Vaage J, Cancer Research, 45, 659 (1985)
  62. De Kesel M, Scandinavian Journal of Immunology, 36, 201 (1992)
  63. Miescher S, Journal of Immunology, 136, 1899 (1986)
  64. Belledegrun A, Cancer Research, 48, 206 (1988)
  65. Sawamura Y, Cancer Research, 49, 1843 (1989)
  66. Topalian SL, Journal of Immunology, 142, 3714 (1989)
  67. Kedar E, Advances in Cancer Research, 59, 245 (1992)
  68. Barth RJ, Journal of Immunology, 144, 1531 (1990)
  69. Rubbert A, International Journal of Cancer, 49, 25 (1991)
  70. Reinhold U, Cancer, 68, 2155 (1991)
  71. MAES H., COCITO C., Synthesis of Cytokines During Tumour Development in Mice Immunized with the Mycobacterial Antigen Complex A60, 10.1046/j.1365-3083.1996.d01-318.x
  72. Peck R, Cellular Immunology, 122, 1 (1989)
  73. Barth R. J., Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes, 10.1084/jem.173.3.647
  74. 74 GW Cox, G Melillo, U Chattopadhyay, D Mullet, RH Fertel, and L Varesio . Tumour necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumouricidal activity . Journal of Immunology, 1992 ; 3290, 6 .
  75. Celada A, Journal of Experimental Medicine, 160, 55 (1984)
  76. Adams DO, Immunological Reviews, 97, 5 (1987)
  77. Narumi S, Journal of Biological Chemistry, 265, 7036 (1990)
  78. Miescher S, Journal of Neurosurgery, 68, 438 (1988)
  79. MAES H., COCITO C, Cancer Prevention by Adoptive Transfer of Antigen 60-Activated Immunocompetent Cells, 10.1046/j.1365-3083.1996.d01-37.x
  80. Maes H, Journal of Cancer Research and Clinical Oncology, 122, 727 (1996)
  81. Stueh DJ, Journal of Experimental Medicine, 169, 1543 (1989)
  82. Keller R, Cancer Research, 50, 1421 (1990)
  83. Higuchi M, Journal of Immunology, 144, 1425 (1990)
  84. Nedwin GE, Journal of Immunology, 135, 2492 (1985)
  85. Nathan C., Role of activated macrophages in antibody-dependent lysis of tumor cells, 10.1084/jem.152.1.183
  86. Nathan CF, Journal of Experimental Medicine, 152, 198 (1980)
  87. Nathan CF, Journal of Clinical Investigation, 79, 319 (1987)
  88. Stuehr DJ, Journal of Immunology, 139, 518 (1987)
  89. McDonough KA, Infectious Immunology, 61, 2763 (1993)
  90. Mc Michael A, Advances in Cancer Research, 59, 227 (1992)
  91. Feinman R, Journal of Immunology, 138, 635 (1987)
  92. 92 DO Adams, and TA Hamilton . Molecular basis of macrophage activation: diversity and its origin. In: Lewis CE, McGee JOD, eds . The Natural Immune System: The Macrophage. Oxford: IRL Press 1992 : 75, 114 .
  93. Hasday JD, Journal of Immunology, 145, 371 (1990)
  94. Janicke R, Journal of Immunology, 144, 1144 (1990)
  95. Rosenberg SA, Science, 233, 1318 (1986)
  96. Greenberg PD, Advances in Immunology, 49, 281 (1991)
  97. Melief CJM, Advances in Cancer Research, 58, 143 (1992)
  98. Borden EC, Cancer, 65, 800 (1990)
Bibliographic reference Cocito, Carlo ; Maes, Hubert. Immunological relatedness of the protective mechanisms against tuberculosis and cancer.. In: European journal of clinical investigation, Vol. 28, no. 1, p. 1-12 (1998)
Permanent URL http://hdl.handle.net/2078.1/13121