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C(16)-methyl corticosteroids are far less allergenic than the non-methylated molecules.

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Baeck, Marie [UCL] Chemelle, Julie-Anne Rasse, Catherine Terreux, Raphaël Goossens, An

C(16)-methyl substitution, interfering with protein binding, and halogenation, seem to reduce the allergenicity of corticosteroid molecules. Hence, when indicated, C(16)-methylated corticosteroids should be preferentially prescribed.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Contact dermatitis" - Vol. 64, no. 6, p. 305-12 (2011)
Peer reviewed yes
issn 1600-0536
Publication status Publié
Affiliations UCL - SSH/LIDAM/SMCS - Support en méthodologie et calcul statistique (plate-forme technologique)
UCL - SSS/IREC/PNEU - Pôle de Pneumologie
ORL et Dermatologie
UCL - (SLuc) Service de dermatologie
MESH Subject Adrenal Cortex Hormones ; Protein Binding ; Skin ; Allergens ; Dermatitis, Allergic Contact ; Dermatologic Agents ; Esters ; Halogenation ; Humans ; Methylation ; Patch Tests
Links
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Bibliographic reference Baeck, Marie ; Chemelle, Julie-Anne ; Rasse, Catherine ; Terreux, Raphaël ; Goossens, An. C(16)-methyl corticosteroids are far less allergenic than the non-methylated molecules.. In: Contact dermatitis, Vol. 64, no. 6, p. 305-12 (2011)
Permanent URL http://hdl.handle.net/2078.1/131122