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A MAGE-1 peptide recognized on HLA-DR15 by CD4(+) T cells.

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Chaux, P Lethé, B Van Snick, Jacques [UCL] Corthals, J Schultz, E S Cambiaso, Cesar [UCL] Boon, Thierry [UCL] van der Bruggen, Pierre [UCL]

Antigens encoded by MAGE genes and recognized by T cells are of interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. Several MAGE-1 peptide that are recognized by CD8(+) cytolytic T lymphocytes have been used in therapeutic vaccination trials. To obtain anti-tumor immune response, vaccines combining peptides recognized by CD8(+) and peptides recognized by CD4(+) T cells might be optimal. We focused therefore on the identification of MAGE peptides recognized by CD4(+) T cells. We report here the identification of MAGE-1 epitope EYVIKVSARVRF, which is presented to CD4(+) T lymphocytes by HLA-DR15. This HLA allele is present in 29 % of Asians and 17 % of Caucasians.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2001
Journal information "European journal of immunology" - Vol. 31, no. 6, p. 1910-6 (2001)
Peer reviewed yes
issn 0014-2980
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Antigen Presentation - immunology ; Antigens, Neoplasm ; CD4-Positive T-Lymphocytes - immunology ; Cell Line, Transformed ; HLA-DR Antigens - immunology ; Humans ; Neoplasm Proteins - genetics - immunology ; Peptides - immunology ; Recombinant Fusion Proteins - genetics - immunology ; Tumor Cells, Cultured
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Bibliographic reference Chaux, P ; Lethé, B ; Van Snick, Jacques ; Corthals, J ; Schultz, E S ; et. al. A MAGE-1 peptide recognized on HLA-DR15 by CD4(+) T cells.. In: European journal of immunology, Vol. 31, no. 6, p. 1910-6 (2001)
Permanent URL http://hdl.handle.net/2078.1/12947