User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function

Primary tabs

Mhallem Gziri, Mina [UCL] Debiève, Frédéric [UCL] De Catte, Luc Mertens, Luc Barréa, Catherine [UCL] Amant, Frédéric

Chemotherapy and especially anthracyclines are associated to cardiotoxicity. To assess this potential risk during pregnancy a clinical case-control trial was conducted. Maternal cardiac function, fetal Doppler and fetal cardiac function were evaluated before and after chemotherapy. Maternal cardiac function was assessed by echocardiography before and after the third cycle of anthracyclines and compared with a control group of 10 non-pregnant women matched for age, type of cancer and anthracycline treatment. Ten fetuses exposed to chemotherapy were compared with 10 control fetuses matched for gestational age and gender. Biometry, amniotic fluid index, fetal Doppler and cardiac function were assessed before and after each cycle of chemotherapy. In all, 108 fetal ultrasounds scans were performed before and after 36 cycles of chemotherapy. Anthracycline exposure did not result in acute maternal and fetal cardiac dysfunction in this small cohort study.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Acta Obstetricia et Gynecologica Scandinavica" - Vol. 91, no. 12, p. 1465-1468 (2012)
Peer reviewed yes
Publisher Munksgaard ((Denmark) Copenhagen)
issn 0001-6349
e-issn 1600-0412
Publication status Publié
Affiliations UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - (SLuc) Service d'obstétrique
UCL - (SLuc) Service de cardiologie pédiatrique
MESH Subject Anthracyclines ; Pregnancy ; Pregnancy Complications, Cardiovascular ; Pregnancy Outcome ; Prospective Studies ; Ultrasonography, Prenatal ; Antibiotics, Antineoplastic ; Belgium ; Case-Control Studies ; Female ; Fetal Heart ; Humans ; Infant, Newborn ; Neoplasms
Links
  1. Pavlidis Nicholas, Cancer and pregnancy: what should we know about the management with systemic treatment of pregnant women with cancer?, 10.1016/s0959-8049(11)70199-x
  2. Gianni Luca, Herman Eugene H., Lipshultz Steven E., Minotti Giorgio, Sarvazyan Narine, Sawyer Douglas B., Anthracycline Cardiotoxicity: From Bench to Bedside, 10.1200/jco.2007.14.9401
  3. Amant Frédéric, Loibl Sibylle, Neven Patrick, Van Calsteren Kristel, Breast cancer in pregnancy, 10.1016/s0140-6736(11)61092-1
  4. Cardonick, Am J Clin Oncol., 33, 221 (2010)
  5. Van Calsteren Kristel, Heyns Liesbeth, De Smet Frank, Van Eycken Liesbet, Gziri Mina Mhallem, Van Gemert Willemijn, Halaska Michael, Vergote Ignace, Ottevanger Nelleke, Amant Frédéric, Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes, 10.1200/jco.2009.23.2801
  6. Amant Frédéric, Van Calsteren Kristel, Halaska Michael J, Gziri Mina Mhallem, Hui Wei, Lagae Lieven, Willemsen Michèl A, Kapusta Livia, Van Calster Ben, Wouters Heidi, Heyns Liesbeth, Han Sileny N, Tomek Viktor, Mertens Luc, Ottevanger Petronella B, Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study, 10.1016/s1470-2045(11)70363-1
  7. Meyer-Wittkopf M., Barth H., Emons G., Schmidt S., Fetal cardiac effects of doxorubicin therapy for carcinoma of the breast during pregnancy: case report and review of the literature, 10.1046/j.1469-0705.2001.00373.x
  8. DeVore Greggory R., Assessing fetal cardiac ventricular function, 10.1016/j.siny.2005.08.009
  9. Hernandez-Andrade E., López-Tenorio J., Figueroa-Diesel H., Sanin-Blair J., Carreras E., Cabero L., Gratacos E., A modified myocardial performance (Tei) index based on the use of valve clicks improves reproducibility of fetal left cardiac function assessment, 10.1002/uog.1959
  10. Baumgärtner Anne K., Oberhoffer R., Jacobs Volker R., Ostermayer E., Menzel H., Voigt M., Schneider K.T.M., Pildner von Steinburg S., Reversible Foetal Cerebral Ventriculomegaly and Cardiomyopathy under Chemotherapy for Maternal AML, 10.1159/000184745
  11. Reynoso, Acta Oncol., 33, 709 (1994)
  12. Ganame Javier, Claus Piet, Eyskens Benedicte, Uyttebroeck Anne, Renard Marleen, D’hooge Jan, Gewillig Marc, Bijnens Bart, Sutherland George R., Mertens Luc, Acute Cardiac Functional and Morphological Changes After Anthracycline Infusions in Children, 10.1016/j.amjcard.2006.10.063
Bibliographic reference Mhallem Gziri, Mina ; Debiève, Frédéric ; De Catte, Luc ; Mertens, Luc ; Barréa, Catherine ; et. al. Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function. In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 91, no. 12, p. 1465-1468 (2012)
Permanent URL http://hdl.handle.net/2078.1/128748