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Histological and immunohistochemical revision of hepatocellular adenomas: a learning experience

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Fonseca, Sandhya [UCL] Hoton, Delphine [UCL] Dardenne, Sabrina [UCL] Annet, Laurence [UCL] Hubert, Catherine [UCL] Godecharles, Sébastien [UCL] Mourin, Anne [UCL] Reding, Raymond [UCL] Otte, Jean-Bernard [UCL] Rahier, Jacques [UCL] Gigot, Jean-François [UCL] Sempoux, Christine [UCL]

Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1 α -inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β -catenin-activated HCA (b-HCA). We reviewed retrospectively our surgical HCA series to learn how to recognize the different subtypes histopathologically and how to interpret adequately their immunohistochemical staining. From January 1992 to January 2012, 37 patients underwent surgical resection for HCA in our institution. Nine had H-HCA (25%) characterized by steatosis and loss of L-FABP expression; 20 had IHCA (55.5%) showing CRP and/or SAA expression, sinusoidal dilatation, and variable inflammation; and 1 patient had both H-HCA and IHCA. In 5 patients (14%), b-HCA with GS and β -catenin nuclear positivity was diagnosed, two already with hepatocellular carcinoma. Two cases (5.5%) remained unclassified. One of the b-HCA showed also the H-HCA histological and immunohistochemical characteristics suggesting a subgroup of β -catenin-activated/HNF1 α -inactivated HCA, another b-HCA exhibited the IHCA histological and immunohistochemical characteristics suggesting a subgroup of β -catenin-activated/inflammatory HCA. Interestingly, three patients had underlying vascular abnormalities. Using the recently published criteria enabled us to classify histopathologically our retrospective HCA surgical series with accurate recognition of b-HCA for which we confirm the higher risk of malignant transformation. We also underlined the association between HCA and vascular abnormalities.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2013
Language Anglais
Journal information "International journal of hepatology" - Vol. 2013, no. 2013, p. 398308 [1-8] (2013)
Peer reviewed yes
Publisher Hindawi Publishing Corporation ((United States) New York, NY)
issn 1936-0533
e-issn 1936-0541
Publication status Publié
Affiliations UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Service de chirurgie et transplantation abdominale
UCL - (SLuc) Service de radiologie
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Bibliographic reference Fonseca, Sandhya ; Hoton, Delphine ; Dardenne, Sabrina ; Annet, Laurence ; Hubert, Catherine ; et. al. Histological and immunohistochemical revision of hepatocellular adenomas: a learning experience. In: International journal of hepatology, Vol. 2013, no. 2013, p. 398308 [1-8] (2013)
Permanent URL http://hdl.handle.net/2078.1/127682