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Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis.

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Boutin, Benoît [UCL] Tajeddine, Nicolas [UCL] Van Der Smissen, Patrick [UCL] Zanou, Nadège [UCL] Van Schoor, Monique [UCL] Mondin, Ludivine [UCL] Courtoy, Pierre J. [UCL] Tombal, Bertrand [UCL] Gailly, Philippe [UCL]

BACKGROUND: Treatment of advanced prostate cancer (PCa) relies on pharmacological or surgical androgen deprivation. However, it is only temporarily efficient. After a few months or years, the tumor relapses despite the absence of androgenic stimulation: a state referred to as hormone-refractory prostate cancer (HRPCa). Although autophagy confers chemoresistance in some cancers, its role in the development of HRPCa remains unknown. METHODS: Autophagic flux was assayed by GFP-LC3 clustering, by LC3-I to LC3-II conversion and transmission electron microscopy. Cell death was detected by sub-G1 quantification and concomitant measurement of transmembrane mitochondrial potential and plasma membrane permeabilization. Inhibition of autophagy was achieved by siRNAs and pharmacological inhibitors. RESULTS: Androgen deprivation or treatment with the anti-androgen bicalutamide promoted autophagy in HRPCa-derived LNCaP cells. This effect was dramatically reduced after depletion of Atg5 and Beclin-1, two canonical autophagy genes, and was associated with an inhibition of the androgen-induced mTOR pathway. The depletion of Atg5 and Beclin-1 significantly increased the level of cell death induced by androgen deprivation or bicalutamide. Finally, the safe anti-malarial drug chloroquine, an inhibitor of autophagy, dramatically increased cell death after androgen deprivation or bicalutamide treatment. CONCLUSION: Taken together, our data suggest that autophagy is a protective mechanism against androgen deprivation in HRPCa cells and that chloroquine could restore hormone dependence. This set of data could lead to the development of new therapeutic strategy against HRPCa. Prostate © 2013 Wiley Periodicals, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2013
Language Anglais
Journal information "The Prostate" - Vol. 73, no. 10, p. 1090-1102 (2013)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 0270-4137
e-issn 1097-0045
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - SSS/DDUV - Institut de Duve
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'urologie
Keywords prostate cancer ; autophagy ; apoptosis ; androgen ; chloroquine
Links
  1. Han Misop, Partin Alan W., Pound Charles R., Epstein Jonathan I., Walsh Patrick C., LONG-TERM BIOCHEMICAL DISEASE-FREE AND CANCER-SPECIFIC SURVIVAL FOLLOWING ANATOMIC RADICAL RETROPUBIC PROSTATECTOMY, 10.1016/s0094-0143(05)70163-4
  2. Petrylak Daniel P., Tangen Catherine M., Hussain Maha H.A., Lara Primo N., Jones Jeffrey A., Taplin Mary Ellen, Burch Patrick A., Berry Donna, Moinpour Carol, Kohli Manish, Benson Mitchell C., Small Eric J., Raghavan Derek, Crawford E. David, Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer, 10.1056/nejmoa041318
  3. Berthold Dominik R., Pond Gregory R., Soban Freidele, de Wit Ronald, Eisenberger Mario, Tannock Ian F., Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study, 10.1200/jco.2007.12.4008
  4. Knudsen K. E., Scher H. I., Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer, 10.1158/1078-0432.ccr-08-2660
  5. Devlin Hong-Lin, Mudryj Maria, Progression of prostate cancer: Multiple pathways to androgen independence, 10.1016/j.canlet.2008.06.007
  6. Shen M. M., Abate-Shen C., Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer, 10.1158/0008-5472.can-07-1271
  7. Sarker D., Reid A. H.M., Yap T. A., de Bono J. S., Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer, 10.1158/1078-0432.ccr-08-0125
  8. Maiuri Maria, Galluzzi Lorenzo, Vicencio Jose, Kepp Oliver, Tasdemir Ezgi, Kroemer Guido, To Die or Not to Die: That is the Autophagic Question, 10.2174/156652408783769616
  9. Cuervo Ana Maria, Autophagy: Many paths to the same end, 10.1023/b:mcbi.0000041848.57020.57
  10. Levine Beth, Kroemer Guido, Autophagy in the Pathogenesis of Disease, 10.1016/j.cell.2007.12.018
  11. Klionsky Daniel J., Abdalla Fabio C., Abeliovich Hagai, Abraham Robert T., Acevedo-Arozena Abraham, Adeli Khosrow, Agholme Lotta, Agnello Maria, Agostinis Patrizia, Aguirre-Ghiso Julio A., Ahn Hyung Jun, Ait-Mohamed Ouardia, Ait-Si-Ali Slimane, Akematsu Takahiko, Akira Shizuo, Al-Younes Hesham M., Al-Zeer Munir A., Albert Matthew L., Albin Roger L., Alegre-Abarrategui Javier, Aleo Maria Francesca, Alirezaei Mehrdad, Almasan Alexandru, Almonte-Becerril Maylin, Amano Atsuo, Amaravadi Ravi K., Amarnath Shoba, Amer Amal O., Andrieu-Abadie Nathalie, Anantharam Vellareddy, Ann David K., Anoopkumar-Dukie Shailendra, Aoki Hiroshi, Apostolova Nadezda, Arancia Giuseppe, Aris John P., Asanuma Katsuhiko, Asare Nana Y.O., Ashida Hisashi, Askanas Valerie, Askew David S., Auberger Patrick, Baba Misuzu, Backues Steven K., Baehrecke Eric H., Bahr Ben A., Bai Xue-Yuan, Bailly Yannick, Baiocchi Robert, Baldini Giulia, Balduini Walter, Ballabio Andrea, Bamber Bruce A., Bampton Edward T.W., Juhász Gábor, Bartholomew Clinton R., Bassham Diane C., Bast Robert C., Batoko Henri, Bay Boon-Huat, Beau Isabelle, Béchet Daniel M., Begley Thomas J., Behl Christian, Behrends Christian, Bekri Soumeya, Bellaire Bryan, Bendall Linda J., Benetti Luca, Berliocchi Laura, Bernardi Henri, Bernassola Francesca, Besteiro Sébastien, Bhatia-Kissova Ingrid, Bi Xiaoning, Biard-Piechaczyk Martine, Blum Janice S., Boise Lawrence H., Bonaldo Paolo, Boone David L., Bornhauser Beat C., Bortoluci Karina R., Bossis Ioannis, Bost Frédéric, Bourquin Jean-Pierre, Boya Patricia, Boyer-Guittaut Michaël, Bozhkov Peter V., Brady Nathan R, Brancolini Claudio, Brech Andreas, Brenman Jay E., Brennand Ana, Bresnick Emery H., Brest Patrick, Bridges Dave, Bristol Molly L., Brookes Paul S., Brown Eric J., Brumell John H., Brunetti-Pierri Nicola, Brunk Ulf T., Bulman Dennis E., Bultman Scott J., Bultynck Geert, Burbulla Lena F., Bursch Wilfried, Butchar Jonathan P., Buzgariu Wanda, Bydlowski Sergio P., Cadwell Ken, Cahová Monika, Cai Dongsheng, Cai Jiyang, Cai Qian, Calabretta Bruno, Calvo-Garrido Javier, Camougrand Nadine, Campanella Michelangelo, Campos-Salinas Jenny, Candi Eleonora, Cao Lizhi, Caplan Allan B., Carding Simon R., Cardoso Sandra M., Carew Jennifer S., Carlin Cathleen R., Carmignac Virginie, Carneiro Leticia A.M., Carra Serena, Caruso Rosario A., Casari Giorgio, Casas Caty, Castino Roberta, Cebollero Eduardo, Cecconi Francesco, Celli Jean, Chaachouay Hassan, Chae Han-Jung, Chai Chee-Yin, Chan David C., Chan Edmond Y., Chang Raymond Chuen-Chung, Che Chi-Ming, Chen Ching-Chow, Chen Guang-Chao, Chen Guo-Qiang, Chen Min, Chen Quan, Chen Steve S.-L., Chen WenLi, Chen Xi, Chen Xiangmei, Chen Xiequn, Chen Ye-Guang, Chen Yingyu, Chen Yongqiang, Chen Yu-Jen, Chen Zhixiang, Cheng Alan, Cheng Christopher H.K., Cheng Yan, Cheong Heesun, Cheong Jae-Ho, Cherry Sara, Chess-Williams Russ, Cheung Zelda H., Chevet Eric, Chiang Hui-Ling, Chiarelli Roberto, Chiba Tomoki, Chin Lih-Shen, Chiou Shih-Hwa, Chisari Francis V., Cho Chi Hin, Cho Dong-Hyung, Choi Augustine M.K., Choi DooSeok, Choi Kyeong Sook, Choi Mary E., Chouaib Salem, Choubey Divaker, Choubey Vinay, Chu Charleen T., Chuang Tsung-Hsien, Chueh Sheau-Huei, Chun Taehoon, Chwae Yong-Joon, Chye Mee-Len, Ciarcia Roberto, Ciriolo Maria R., Clague Michael J., Clark Robert S.B., Clarke Peter G.H., Clarke Robert, Codogno Patrice, Coller Hilary A., Colombo María I., Comincini Sergio, Condello Maria, Condorelli Fabrizio, Cookson Mark R., Coombs Graham H., Coppens Isabelle, Corbalan Ramon, Cossart Pascale, Costelli Paola, Costes Safia, Coto-Montes Ana, Couve Eduardo, Coxon Fraser P., Cregg James M., Crespo José L., Cronjé Marianne J., Cuervo Ana Maria, Cullen Joseph J., Czaja Mark J., D'Amelio Marcello, Darfeuille-Michaud Arlette, Davids Lester M., Davies Faith E., De Felici Massimo, de Groot John F., de Haan Cornelis A.M., De Martino Luisa, De Milito Angelo, De Tata Vincenzo, Debnath Jayanta, Degterev Alexei, Dehay Benjamin, Delbridge Lea M.D., Demarchi Francesca, Deng Yi Zhen, Dengjel Jörn, Dent Paul, Denton Donna, Deretic Vojo, Desai Shyamal D., Devenish Rodney J., Di Gioacchino Mario, Di Paolo Gilbert, Di Pietro Chiara, Díaz-Araya Guillermo, Díaz-Laviada Inés, Diaz-Meco Maria T., Diaz-Nido Javier, Dikic Ivan, Dinesh-Kumar Savithramma P., Ding Wen-Xing, Distelhorst Clark W., Diwan Abhinav, Djavaheri-Mergny Mojgan, Dokudovskaya Svetlana, Dong Zheng, Dorsey Frank C., Dosenko Victor, Dowling James J., Doxsey Stephen, Dreux Marlène, Drew Mark E., Duan Qiuhong, Duchosal Michel A., Duff Karen E., Dugail Isabelle, Durbeej Madeleine, Duszenko Michael, Edelstein Charles L., Edinger Aimee L., Egea Gustavo, Eichinger Ludwig, Eissa N. Tony, Ekmekcioglu Suhendan, El-Deiry Wafik S., Elazar Zvulun, Elgendy Mohamed, Ellerby Lisa M., Eng Kai Er, Engelbrecht Anna-Mart, Engelender Simone, Erenpreisa Jekaterina, Escalante Ricardo, Esclatine Audrey, Eskelinen Eeva-Liisa, Espert Lucile, Espina Virginia, Fan Huizhou, Fan Jia, Fan Qi-Wen, Fan Zhen, Fang Shengyun, Fang Yongqi, Fanto Manolis, Fanzani Alessandro, Farkas Thomas, Farre Jean-Claude, Faure Mathias, Fechheimer Marcus, Feng Carl G., Feng Jian, Feng Qili, Feng Youji, Fésüs László, Feuer Ralph, Figueiredo-Pereira Maria E., Fimia Gian Maria, Fingar Diane C., Finkbeiner Steven, Finkel Toren, Finley Kim D., Fiorito Filomena, Fisher Edward A., Fisher Paul B., Flajolet Marc, Florez-McClure Maria L., Florio Salvatore, Fon Edward A., Fornai Francesco, Fortunato Franco, Fotedar Rati, Fowler Daniel H., Fox Howard S., Franco Rodrigo, Frankel Lisa B., Fransen Marc, Fuentes José M., Fueyo Juan, Fujii Jun, Fujisaki Kozo, Fujita Eriko, Fukuda Mitsunori, Furukawa Ruth H., Gaestel Matthias, Gailly Philippe, Gajewska Malgorzata, Galliot Brigitte, Galy Vincent, Ganesh Subramaniam, Ganetzky Barry, Ganley Ian G., Gao Fen-Biao, Gao George F., Gao Jinming, Garcia Lorena, Garcia-Manero Guillermo, Garcia-Marcos Mikel, Garmyn Marjan, Gartel Andrei L., Gatti Evelina, Gautel Mathias, Gawriluk Thomas R., Gegg Matthew E., Geng Jiefei, Germain Marc, Gestwicki Jason E., Gewirtz David A., Ghavami Saeid, Ghosh Pradipta, Giammarioli Anna M., Giatromanolaki Alexandra N., Gibson Spencer B., Gilkerson Robert W., Ginger Michael L., Ginsberg Henry N., Golab Jakub, Goligorsky Michael S., Golstein Pierre, Gomez-Manzano Candelaria, Goncu Ebru, Gongora Céline, Gonzalez Claudio D., Gonzalez Ramon, González-Estévez Cristina, González-Polo Rosa Ana, Gonzalez-Rey Elena, Gorbunov Nikolai V., Gorski Sharon, Goruppi Sandro, Gottlieb Roberta A., Gozuacik Devrim, Granato Giovanna Elvira, Grant Gary D., Green Kim N., Gregorc Ales, Gros Frédéric, Grose Charles, Grunt Thomas W., Gual Philippe, Guan Jun-Lin, Guan Kun-Liang, Guichard Sylvie M., Gukovskaya Anna S., Gukovsky Ilya, Gunst Jan, Gustafsson Åsa B., Halayko Andrew J., Hale Amber N., Halonen Sandra K., Hamasaki Maho, Han Feng, Han Ting, Hancock Michael K., Hansen Malene, Harada Hisashi, Harada Masaru, Hardt Stefan E., Harper J. Wade, Harris Adrian L., Harris James, Harris Steven D., Hashimoto Makoto, Haspel Jeffrey A., Hayashi Shin-ichiro, Hazelhurst Lori A., He Congcong, He You-Wen, Hébert Marie-Josée, Heidenreich Kim A., Helfrich Miep H., Helgason Gudmundur V., Henske Elizabeth P., Herman Brian, Herman Paul K., Hetz Claudio, Hilfiker Sabine, Hill Joseph A., Hocking Lynne J., Hofman Paul, Hofmann Thomas G., Höhfeld Jörg, Holyoake Tessa L., Hong Ming-Huang, Hood David A., Hotamisligil Gökhan S., Houwerzijl Ewout J., Høyer-Hansen Maria, Hu Bingren, Hu Chien-an A., Hu Hong-Ming, Hua Ya, Huang Canhua, Huang Ju, Huang Shengbing, Huang Wei-Pang, Huber Tobias B., Huh Won-Ki, Hung Tai-Ho, Hupp Ted R., Hur Gang Min, Hurley James B., Hussain Sabah N.A., Hussey Patrick J., Hwang Jung Jin, Hwang Seungmin, Ichihara Atsuhiro, Ilkhanizadeh Shirin, Inoki Ken, Into Takeshi, Iovane Valentina, Iovanna Juan L., Ip Nancy Y., Isaka Yoshitaka, Ishida Hiroyuki, Isidoro Ciro, Isobe Ken-ichi, Iwasaki Akiko, Izquierdo Marta, Izumi Yotaro, Jaakkola Panu M., Jäättelä Marja, Jackson George R., Jackson William T., Janji Bassam, Jendrach Marina, Jeon Ju-Hong, Jeung Eui-Bae, Jiang Hong, Jiang Hongchi, Jiang Jean X., Jiang Ming, Jiang Qing, Jiang Xuejun, Jiang Xuejun, Jiménez Alberto, Jin Meiyan, Jin Shengkan V., Joe Cheol O., Johansen Terje, Johnson Daniel E., Johnson Gail V.W., Jones Nicola L., Joseph Bertrand, Joseph Suresh K., Joubert Annie M., Juhász Gábor, Juillerat-Jeanneret Lucienne, Jung Chang Hwa, Jung Yong-Keun, Kaarniranta Kai, Kaasik Allen, Kabuta Tomohiro, Kadowaki Motoni, Kågedal Katarina, Kamada Yoshiaki, Kaminskyy Vitaliy O., Kampinga Harm H., Kanamori Hiromitsu, Kang Chanhee, Kang Khong Bee, Kang Kwang Il, Kang Rui, Kang Yoon-A, Kanki Tomotake, Kanneganti Thirumala-Devi, Kanno Haruo, Kanthasamy Anumantha G., Kanthasamy Arthi, Karantza Vassiliki, Kaushal Gur P., Kaushik Susmita, Kawazoe Yoshinori, Ke Po-Yuan, Kehrl John H., Kelekar Ameeta, Kerkhoff Claus, Kessel David H., Khalil Hany, Kiel Jan A.K.W., Kiger Amy A., Kihara Akio, Kim Deok Ryong, Kim Do-Hyung, Kim Dong-Hou, Kim Eun-Kyoung, Kim Hyung-Ryong, Kim Jae-Sung, Kim Jeong Hun, Kim Jin Cheon, Kim John K., Kim Peter K., Kim Seong Who, Kim Yong-Sun, Kim Yonghyun, Kimchi Adi, Kimmelman Alec C., King Jason S., Kinsella Timothy J., Kirkin Vladimir, Kirshenbaum Lorrie A., Kitamoto Katsuhiko, Kitazato Kaio, Klein Ludger, Klimecki Walter T., Klucken Jochen, Knecht Erwin, Ko Ben C.B., Koch Jan C., Koga Hiroshi, Koh Jae-Young, Koh Young Ho, Koike Masato, Komatsu Masaaki, Kominami Eiki, Kong Hee Jeong, Kong Wei-Jia, Korolchuk Viktor I., Kotake Yaichiro, Koukourakis Michael I., Flores Juan B. Kouri, Kovács Attila L., Kraft Claudine, Krainc Dimitri, Krämer Helmut, Kretz-Remy Carole, Krichevsky Anna M., Kroemer Guido, Krüger Rejko, Krut Oleg, Ktistakis Nicholas T., Kuan Chia-Yi, Kucharczyk Roza, Kumar Ashok, Kumar Raj, Kumar Sharad, Kundu Mondira, Kung Hsing-Jien, Kurz Tino, Kwon Ho Jeong, La Spada Albert R., Lafont Frank, Lamark Trond, Landry Jacques, Lane Jon D., Lapaquette Pierre, Laporte Jocelyn F., László Lajos, Lavandero Sergio, Lavoie Josée N., Layfield Robert, Lazo Pedro A., Le Weidong, Le Cam Laurent, Ledbetter Daniel J., Lee Alvin J.X., Lee Byung-Wan, Lee Gyun Min, Lee Jongdae, lee Ju-hyun, Lee Michael, Lee Myung-Shik, Lee Sug Hyung, Leeuwenburgh Christiaan, Legembre Patrick, Legouis Renaud, Lehmann Michael, Lei Huan-Yao, Lei Qun-Ying, Leib David A., Leiro José, Lemasters John J., Lemoine Antoinette, Lesniak Maciej S., Lev Dina, Levenson Victor V., Levine Beth, Levy Efrat, Li Faqiang, Li Jun-Lin, Li Lian, Li Sheng, Li Weijie, Li Xue-Jun, Li Yan-Bo, Li Yi-Ping, Liang Chengyu, Liang Qiangrong, Liao Yung-Feng, Liberski Pawel P., Lieberman Andrew, Lim Hyunjung J., Lim Kah-Leong, Lim Kyu, Lin Chiou-Feng, Lin Fu-Cheng, Lin Jian, Lin Jiandie D., Lin Kui, Lin Wan-Wan, Lin Weei-Chin, Lin Yi-Ling, Linden Rafael, Lingor Paul, Lippincott-Schwartz Jennifer, Lisanti Michael P., Liton Paloma B., Liu Bo, Liu Chun-Feng, Liu Kaiyu, Liu Leyuan, Liu Qiong A., Liu Wei, Liu Young-Chau, Liu Yule, Lockshin Richard A., Lok Chun-Nam, Lonial Sagar, Loos Benjamin, Lopez-Berestein Gabriel, López-Otín Carlos, Lossi Laura, Lotze Michael T., Low Peter, Lu Binfeng, Lu Bingwei, Lu Bo, Lu Zhen, Luciano Fréderic, Lukacs Nicholas W., Lund Anders H., Lynch-Day Melinda A., Ma Yong, Macian Fernando, MacKeigan Jeff P., Macleod Kay F., Madeo Frank, Maiuri Luigi, Maiuri Maria Chiara, Malagoli Davide, Malicdan May Christine V., Malorni Walter, Man Na, Mandelkow Eva-Maria, Manon Stephen, Manov Irena, Mao Kai, Mao Xiang, Mao Zixu, Marambaud Philippe, Marazziti Daniela, Marcel Yves L., Marchbank Katie, Marchetti Piero, Marciniak Stefan J., Marcondes Mateus, Mardi Mohsen, Marfe Gabriella, Mariño Guillermo, Markaki Maria, Marten Mark R., Martin Seamus J., Martinand-Mari Camille, Martinet Wim, Martinez-Vicente Marta, Masini Matilde, Matarrese Paola, Matsuo Saburo, Matteoni Raffaele, Mayer Andreas, Mazure Nathalie M., McConkey David J., McConnell Melanie J., McDermott Catherine, McDonald Christine, McInerney Gerald M., McKenna Sharon L., McLaughlin BethAnn, McLean Pamela J., McMaster Christopher R., McQuibban G. Angus, Meijer Alfred J., Meisler Miriam H., Meléndez Alicia, Melia Thomas J., Melino Gerry, Mena Maria A., Menendez Javier A., Menna-Barreto Rubem F. S., Menon Manoj B., Menzies Fiona M., Mercer Carol A., Merighi Adalberto, Merry Diane E., Meschini Stefania, Meyer Christian G., Meyer Thomas F., Miao Chao-Yu, Miao Jun-Ying, Michels Paul A.M., Michiels Carine, Mijaljica Dalibor, Milojkovic Ana, Minucci Saverio, Miracco Clelia, Miranti Cindy K., Mitroulis Ioannis, Miyazawa Keisuke, Mizushima Noboru, Mograbi Baharia, Mohseni Simin, Molero Xavier, Mollereau Bertrand, Mollinedo Faustino, Momoi Takashi, Monastyrska Iryna, Monick Martha M., Monteiro Mervyn J., Moore Michael N., Mora Rodrigo, Moreau Kevin, Moreira Paula I., Moriyasu Yuji, Moscat Jorge, Mostowy Serge, Mottram Jeremy C., Motyl Tomasz, Moussa Charbel E.-H., Müller Sylke, Muller Sylviane, Münger Karl, Münz Christian, Murphy Leon O., Murphy Maureen E., Musarò Antonio, Mysorekar Indira, Nagata Eiichiro, Nagata Kazuhiro, Nahimana Aimable, Nair Usha, Nakagawa Toshiyuki, Nakahira Kiichi, Nakano Hiroyasu, Nakatogawa Hitoshi, Nanjundan Meera, Naqvi Naweed I., Narendra Derek P., Narita Masashi, Navarro Miguel, Nawrocki Steffan T., Nazarko Taras Y., Nemchenko Andriy, Netea Mihai G., Neufeld Thomas P., Ney Paul A., Nezis Ioannis P., Nguyen Huu Phuc, Nie Daotai, Nishino Ichizo, Nislow Corey, Nixon Ralph A., Noda Takeshi, Noegel Angelika A., Nogalska Anna, Noguchi Satoru, Notterpek Lucia, Novak Ivana, Nozaki Tomoyoshi, Nukina Nobuyuki, Nürnberger Thorsten, Nyfeler Beat, Obara Keisuke, Oberley Terry D., Oddo Salvatore, Ogawa Michinaga, Ohashi Toya, Okamoto Koji, Oleinick Nancy L., Oliver F. Javier, Olsen Laura J., Olsson Stefan, Opota Onya, Osborne Timothy F., Ostrander Gary K., Otsu Kinya, Ou Jing-hsiung James, Ouimet Mireille, Overholtzer Michael, Ozpolat Bulent, Paganetti Paolo, Pagnini Ugo, Pallet Nicolas, Palmer Glen E., Palumbo Camilla, Pan Tianhong, Panaretakis Theocharis, Pandey Udai Bhan, Papackova Zuzana, Papassideri Issidora, Paris Irmgard, Park Junsoo, Park Ohkmae K., Parys Jan B., Parzych Katherine R., Patschan Susann, Patterson Cam, Pattingre Sophie, Pawelek John M., Peng Jianxin, Perlmutter David H., Perrotta Ida, Perry George, Pervaiz Shazib, Peter Matthias, Peters Godefridus J., Petersen Morten, Petrovski Goran, Phang James M., Piacentini Mauro, Pierre Philippe, Pierrefite-Carle Valérie, Pierron Gérard, Pinkas-Kramarski Ronit, Piras Antonio, Piri Natik, Platanias Leonidas C., Pöggeler Stefanie, Poirot Marc, Poletti Angelo, Poüs Christian, Pozuelo-Rubio Mercedes, Prætorius-Ibba Mette, Prasad Anil, Prescott Mark, Priault Muriel, Produit-Zengaffinen Nathalie, Progulske-Fox Ann, Proikas-Cezanne Tassula, Przedborski Serge, Przyklenk Karin, Puertollano Rosa, Puyal Julien, Qian Shu-Bing, Qin Liang, Qin Zheng-Hong, Quaggin Susan E., Raben Nina, Rabinowich Hannah, Rabkin Simon W., Rahman Irfan, Rami Abdelhaq, Ramm Georg, Randall Glenn, Randow Felix, Rao V. Ashutosh, Rathmell Jeffrey C., Ravikumar Brinda, Ray Swapan K., Reed Bruce H., Reed John C., Reggiori Fulvio, Régnier-Vigouroux Anne, Reichert Andreas S., Reiners, Jr. John J., Reiter Russel J., Ren Jun, Revuelta José L., Rhodes Christopher J., Ritis Konstantinos, Rizzo Elizete, Robbins Jeffrey, Roberge Michel, Roca Hernan, Roccheri Maria C., Rocchi Stephane, Rodemann H. Peter, Rodríguez de Córdoba Santiago, Rohrer Bärbel, Roninson Igor B., Rosen Kirill, Rost-Roszkowska Magdalena M., Rouis Mustapha, Rouschop Kasper M.A., Rovetta Francesca, Rubin Brian P., Rubinsztein David C., Ruckdeschel Klaus, Rucker Edmund B., Rudich Assaf, Rudolf Emil, Ruiz-Opazo Nelson, Russo Rossella, Rusten Tor Erik, Ryan Kevin M., Ryter Stefan W., Sabatini David M., Sadoshima Junichi, Saha Tapas, Saitoh Tatsuya, Sakagami Hiroshi, Sakai Yasuyoshi, Salekdeh Ghasem Hoseini, Salomoni Paolo, Salvaterra Paul M., Salvesen Guy, Salvioli Rosa, Sanchez Anthony M.J., Sánchez-Alcázar José A., Sánchez-Prieto Ricardo, Sandri Marco, Sankar Uma, Sansanwal Poonam, Santambrogio Laura, Saran Shweta, Sarkar Sovan, Sarwal Minnie, Sasakawa Chihiro, Sasnauskiene Ausra, Sass Miklós, Sato Ken, Sato Miyuki, Schapira Anthony H.V., Scharl Michael, Schätzl Hermann M., Scheper Wiep, Schiaffino Stefano, Schneider Claudio, Schneider Marion E., Schneider-Stock Regine, Schoenlein Patricia V., Schorderet Daniel F., Schüller Christoph, Schwartz Gary K., Scorrano Luca, Sealy Linda, Seglen Per O., Segura-Aguilar Juan, Seiliez Iban, Seleverstov Oleksandr, Sell Christian, Seo Jong Bok, Separovic Duska, Setaluri Vijayasaradhi, Setoguchi Takao, Settembre Carmine, Shacka John J., Shanmugam Mala, Shapiro Irving M., Shaulian Eitan, Shaw Reuben J., Shelhamer James H., Shen Han-Ming, Shen Wei-Chiang, Sheng Zu-Hang, Shi Yang, Shibuya Kenichi, Shidoji Yoshihiro, Shieh Jeng-Jer, Shih Chwen-Ming, Shimada Yohta, Shimizu Shigeomi, Shintani Takahiro, Shirihai Orian S., Shore Gordon C., Sibirny Andriy A., Sidhu Stan B., Sikorska Beata, Silva-Zacarin Elaine C.M., Simmons Alison, Simon Anna Katharina, Simon Hans-Uwe, Simone Cristiano, Simonsen Anne, Sinclair David A., Singh Rajat, Sinha Debasish, Sinicrope Frank A., Sirko Agnieszka, Siu Parco M., Sivridis Efthimios, Skop Vojtech, Skulachev Vladimir P., Slack Ruth S., Smaili Soraya S., Smith Duncan R., Soengas Maria S., Soldati Thierry, Song Xueqin, Sood Anil K., Soong Tuck Wah, Sotgia Federica, Spector Stephen A., Spies Claudia D., Springer Wolfdieter, Srinivasula Srinivasa M., Stefanis Leonidas, Steffan Joan S., Stendel Ruediger, Stenmark Harald, Stephanou Anastasis, Stern Stephan T., Sternberg Cinthya, Stork Björn, Strålfors Peter, Subauste Carlos S., Sui Xinbing, Sulzer David, Sun Jiaren, Sun Shi-Yong, Sun Zhi-Jun, Sung Joseph J.Y., Suzuki Kuninori, Suzuki Toshihiko, Swanson Michele S., Swanton Charles, Sweeney Sean T., Sy Lai-King, Szabadkai György, Tabas Ira, Taegtmeyer Heinrich, Tafani Marco, Takács-Vellai Krisztina, Takano Yoshitaka, Takegawa Kaoru, Takemura Genzou, Takeshita Fumihiko, Talbot Nicholas J., Tan Kevin S.W., Tanaka Keiji, Tanaka Kozo, Tang Daolin, Tang Dingzhong, Tanida Isei, Tannous Bakhos A., Tavernarakis Nektarios, Taylor Graham S., Taylor Gregory A., Taylor J. Paul, Terada Lance S., Terman Alexei, Tettamanti Gianluca, Thevissen Karin, Thompson Craig B., Thorburn Andrew, Thumm Michael, Tian FengFeng, Tian Yuan, Tocchini-Valentini Glauco, Tolkovsky Aviva M., Tomino Yasuhiko, Tönges Lars, Tooze Sharon A., Tournier Cathy, Tower John, Towns Roberto, Trajkovic Vladimir, Travassos Leonardo H., Tsai Ting-Fen, Tschan Mario P., Tsubata Takeshi, Tsung Allan, Turk Boris, Turner Lorianne S., Tyagi Suresh C., Uchiyama Yasuo, Ueno Takashi, Umekawa Midori, Umemiya-Shirafuji Rika, Unni Vivek K., Vaccaro Maria I., Valente Enza Maria, Van den Berghe Greet, van der Klei Ida J., van Doorn Wouter G., van Dyk Linda F., van Egmond Marjolein, van Grunsven Leo A., Vandenabeele Peter, Vandenberghe Wim P., Vanhorebeek Ilse, Vaquero Eva C., Velasco Guillermo, Vellai Tibor, Vicencio José Miguel, Vierstra Richard D., Vila Miquel, Vindis Cécile, Viola Giampietro, Viscomi Maria Teresa, Voitsekhovskaja Olga V., von Haefen Clarissa, Votruba Marcela, Wada Keiji, Wade-Martins Richard, Walker Cheryl L., Walsh Craig M., Walter Jochen, Wan Xiang-Bo, Wang Aimin, Wang Chenguang, Wang Dawei, Wang Fan, Wang Fen, Wang Guanghui, Wang Haichao, Wang Hong-Gang, Wang Horng-Dar, Wang Jin, Wang Ke, Wang Mei, Wang Richard C., Wang Xinglong, Wang Xiujie J., Wang Ying-Jan, Wang Yipeng, Wang Zhen-Bo, Wang Zhigang Charles, Wang Zhinong, Wansink Derick G., Ward Diane M., Watada Hirotaka, Waters Sarah L., Webster Paul, Wei Lixin, Weihl Conrad C., Weiss William A., Welford Scott M., Wen Long-Ping, Whitehouse Caroline A., Whitton J. Lindsay, Whitworth Alexander J., Wileman Tom, Wiley John W., Wilkinson Simon, Willbold Dieter, Williams Roger L., Williamson Peter R., Wouters Bradly G., Wu Chenghan, Wu Dao-Cheng, Wu William K.K., Wyttenbach Andreas, Xavier Ramnik J., Xi Zhijun, Xia Pu, Xiao Gengfu, Xie Zhiping, Xie Zhonglin, Xu Da-zhi, Xu Jianzhen, Xu Liang, Xu Xiaolei, Yamamoto Ai, Yamamoto Akitsugu, Yamashina Shunhei, Yamashita Michiaki, Yan Xianghua, Yanagida Mitsuhiro, Yang Dun-Sheng, Yang Elizabeth, Yang Jin-Ming, Yang Shi Yu, Yang Wannian, Yang Wei Yuan, Yang Zhifen, Yao Meng-Chao, Yao Tso-Pang, Yeganeh Behzad, Yen Wei-Lien, Yin Jia-Jing, Yin Xiao-Ming, Yoo Ook-Joon, Yoon Gyesoon, Yoon Seung-Yong, Yorimitsu Tomohiro, Yoshikawa Yuko, Yoshimori Tamotsu, Yoshimoto Kohki, You Ho Jin, Youle Richard J., Younes Anas, Yu Li, Yu Long, Yu Seong-Woon, Yu Wai Haung, Yuan Zhi-Min, Yue Zhenyu, Yun Cheol-Heui, Yuzaki Michisuke, Zabirnyk Olga, Silva-Zacarin Elaine, Zacks David, Zacksenhaus Eldad, Zaffaroni Nadia, Zakeri Zahra, Zeh, III Herbert J., Zeitlin Scott O., Zhang Hong, Zhang Hui-Ling, Zhang Jianhua, Zhang Jing-Pu, Zhang Lin, Zhang Long, Zhang Ming-Yong, Zhang Xu Dong, Zhao Mantong, Zhao Yi-Fang, Zhao Ying, Zhao Zhizhuang J., Zheng Xiaoxiang, Zhivotovsky Boris, Zhong Qing, Zhou Cong-Zhao, Zhu Changlian, Zhu Wei-Guo, Zhu Xiao-Feng, Zhu Xiongwei, Zhu Yuangang, Zoladek Teresa, Zong Wei-Xing, Zorzano Antonio, Zschocke Jürgen, Zuckerbraun Brian, Guidelines for the use and interpretation of assays for monitoring autophagy, 10.4161/auto.19496
  12. Galluzzi Lorenzo, Morselli Eugenia, Vicencio José Miguel, Kepp Oliver, Joza Nicholas, Tajeddine Nicolas, Kroemer Guido, Life, death and burial: multifaceted impact of autophagy, 10.1042/bst0360786
  13. Tsujimoto Y, Shimizu S, Another way to die: autophagic programmed cell death, 10.1038/sj.cdd.4401777
  14. BURSCH W., ELLINGER A., GERNER CH., FRÖHWEIN U., SCHULTE-HERMANN R., Programmed Cell Death (PCD): Apoptosis, Autophagic PCD, or Others?, 10.1111/j.1749-6632.2000.tb05594.x
  15. Glick Danielle, Barth Sandra, Macleod Kay F., Autophagy: cellular and molecular mechanisms, 10.1002/path.2697
  16. Kroemer Guido, Levine Beth, Autophagic cell death: the story of a misnomer, 10.1038/nrm2529
  17. Veldscholte J., Ris-Stalpers C., Kuiper G.G.J.M., Jenster G., Berrevoets C., Claassen E., van Rooij H.C.J., Trapman J., Brinkmann A.O., Mulder E., A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens, 10.1016/s0006-291x(05)80067-1
  18. Mizushima Noboru, Yoshimori Tamotsu, How to Interpret LC3 Immunoblotting, 10.4161/auto.4600
  19. Baron Silvère, Manin Michèle, Beaudoin Claude, Leotoing Laurent, Communal Yves, Veyssiere Georges, Morel Laurent, Androgen Receptor Mediates Non-genomic Activation of Phosphatidylinositol 3-OH Kinase in Androgen-sensitive Epithelial Cells, 10.1074/jbc.m306143200
  20. Ni Hong-Min, Bockus Abigail, Wozniak Ann L., Jones Kellyann, Weinman Steven, Yin Xiao-Ming, Ding Wen-Xing, Dissecting the dynamic turnover of GFP-LC3 in the autolysosome, 10.4161/auto.7.2.14181
  21. Li Mengqiang, Jiang Xuejun, Liu Di, Na Yanqun, Gao George F., Xi Zhijun, Autophagy protects LNCaP cells under androgen deprivation conditions, 10.4161/auto.5209
  22. Bennett H L, Fleming J T, O'Prey J, Ryan K M, Leung H Y, Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells, 10.1038/cddis.2010.50
  23. Chhipa Rishi Raj, Wu Yue, Ip Clement, AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia, 10.1016/j.cellsig.2011.04.008
  24. Xu Youyuan, Chen Shao-Yong, Ross Kenneth N., Balk Steven P., Androgens Induce Prostate Cancer Cell Proliferation through Mammalian Target of Rapamycin Activation and Post-transcriptional Increases in Cyclin D Proteins, 10.1158/0008-5472.can-05-4472
  25. Sun Mei, Yang Lin, Feldman Richard I., Sun Xia-meng, Bhalla Kapil N., Jove Richard, Nicosia Santo V., Cheng Jin Q., Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src, 10.1074/jbc.m306295200
  26. Eisenberg-Lerner A, Bialik S, Simon H-U, Kimchi A, Life and death partners: apoptosis, autophagy and the cross-talk between them, 10.1038/cdd.2009.33
  27. Maiuri M. Chiara, Zalckvar Einat, Kimchi Adi, Kroemer Guido, Self-eating and self-killing: crosstalk between autophagy and apoptosis, 10.1038/nrm2239
  28. Livesey, Curr Opin Investig Drugs, 10, 1269 (2009)
Bibliographic reference Boutin, Benoît ; Tajeddine, Nicolas ; Van Der Smissen, Patrick ; Zanou, Nadège ; Van Schoor, Monique ; et. al. Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis.. In: The Prostate, Vol. 73, no. 10, p. 1090-1102 (2013)
Permanent URL http://hdl.handle.net/2078.1/127163