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Sildenafil therapy for neonatal and childhood pulmonary hypertensive vascular disease.

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Humpl, Tilman Reyes, Janette T Erickson, Simon Armano, Ruth [UCL] Holtby, Helen Adatia, Ian

In children under 5 years of age with severe pulmonary hypertension, sildenafil therapy resulted in prolonged hemodynamic improvements without adverse effects. Sildenafil attenuated rebound pulmonary hypertension after withdrawal of inhaled nitric oxide.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2011
Language Anglais
Journal information "Cardiology in the Young" - Vol. 21, no.2, p. 187-193 (2011)
Peer reviewed yes
Publisher Cambridge University Press ((United Kingdom) Cambridge)
issn 1047-9511
e-issn 1467-1107
Publication status Publié
Affiliation UCL - (SLuc) Service de pédiatrie spécialisée
MESH Subject Administration, Oral ; Infant ; Infant, Newborn ; Male ; Phosphodiesterase 5 Inhibitors ; Piperazines ; Pulmonary Wedge Pressure ; Purines ; Retrospective Studies ; Sulfones ; Treatment Outcome ; Cardiac Catheterization ; Ventricular Function, Right ; Ventricular Pressure ; Child, Preschool ; Dose-Response Relationship, Drug ; Echocardiography ; Female ; Follow-Up Studies ; Humans ; Hypertension, Pulmonary
Links
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  2. Khemani E., McElhinney D. B., Rhein L., Andrade O., Lacro R. V., Thomas K. C., Mullen M. P., Pulmonary Artery Hypertension in Formerly Premature Infants With Bronchopulmonary Dysplasia: Clinical Features and Outcomes in the Surfactant Era, 10.1542/peds.2007-0971
  3. Ghofrani Hossein A, Pepke-Zaba Joanna, Barbera Joan A, Channick Richard, Keogh Anne M, Gomez-Sanchez Miguel A, Kneussl Meinhard, Grimminger Friedrich, Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension, 10.1016/j.jacc.2004.02.031
  4. Humpl T., Beneficial Effect of Oral Sildenafil Therapy on Childhood Pulmonary Arterial Hypertension: Twelve-Month Clinical Trial of a Single-Drug, Open-Label, Pilot Study, 10.1161/circulationaha.104.473371
  5. Sastry B.K.S., Narasimhan C., Reddy N.Krishna, Raju B.Soma, Clinical efficacy of sildenafil in primary pulmonary hypertension, 10.1016/j.jacc.2003.10.056
  6. Michelakis E. D., Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension, 10.1161/01.cir.0000099502.17776.c2
  7. Mourani Peter M., Sontag Marci K., Ivy D. Dunbar, Abman Steven H., Effects of Long-Term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease, 10.1016/j.jpeds.2008.09.021
  8. Steinhorn Robin H., Kinsella John P., Pierce Christine, Butrous Ghazwan, Dilleen Maria, Oakes Michael, Wessel David L., Intravenous Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension, 10.1016/j.jpeds.2009.06.012
  9. Schulze-Neick I., Intravenous Sildenafil Is a Potent Pulmonary Vasodilator in Children With Congenital Heart Disease, 10.1161/01.cir.0000087384.76615.60
  10. Stocker Christian, Penny Daniel J., Brizard Christian P., Cochrane Andrew D., Soto Rodrigo, Shekerdemian Lara S., Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after cardiac surgery, 10.1007/s00134-003-2016-4
  11. Noori Shahab, Friedlich Philippe, Wong Pierre, Garingo Arlene, Seri Istvan, Cardiovascular Effects of Sildenafil in Neonates and Infants with Congenital Diaphragmatic Hernia and Pulmonary Hypertension, 10.1159/000097125
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  13. Grunig E., Weissmann S., Ehlken N., Fijalkowska A., Fischer C., Fourme T., Galie N., Ghofrani A., Harrison R. E., Huez S., Humbert M., Janssen B., Kober J., Koehler R., Machado R. D., Mereles D., Naeije R., Olschewski H., Provencher S., Reichenberger F., Retailleau K., Rocchi G., Simonneau G., Torbicki A., Trembath R., Seeger W., Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension: Results of a Multicenter European Analysis of Pulmonary Artery Pressure Response to Exercise and Hypoxia, 10.1161/circulationaha.108.800938
  14. Adatia Ian, Improving the Outcome of Childhood Pulmonary Arterial Hypertension, 10.1016/j.jacc.2005.05.038
  15. Adatia, The Natural and Modified History of Congenital Heart Disease, 513 (2004)
  16. Atz Andrew M, Adatia Ian, Wessel David L, Rebound Pulmonary Hypertension After Inhalation of Nitric Oxide, 10.1016/s0003-4975(96)00542-5
  17. Miller O.I., Tang S.F., Keech A., Celermajer D.S., Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide, 10.1016/s0140-6736(95)92681-x
  18. Namachivayam Poongundran, Theilen Ulf, Butt Warwick W., Cooper Sian M., Penny Daniel J., Shekerdemian Lara S., Sildenafil Prevents Rebound Pulmonary Hypertension after Withdrawal of Nitric Oxide in Children, 10.1164/rccm.200605-694oc
  19. Cordell William H., Retinal Effects of 6 Months of Daily Use of Tadalafil or Sildenafil, 10.1001/archophthalmol.2009.36
  20. Keller Roberta L., Moore Phillip, Teitel David, Hawgood Samuel, McQuitty John, Fineman Jeffrey R., Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy : , 10.1097/01.pcc.0000244401.53189.cb
Bibliographic reference Humpl, Tilman ; Reyes, Janette T ; Erickson, Simon ; Armano, Ruth ; Holtby, Helen ; et. al. Sildenafil therapy for neonatal and childhood pulmonary hypertensive vascular disease.. In: Cardiology in the Young, Vol. 21, no.2, p. 187-193 (2011)
Permanent URL http://hdl.handle.net/2078.1/126305