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Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model.

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Ohtomo, Shuichi Izuhara, Yuko Nangaku, Masaomi Dan, Takashi Ito, Sadayoshi Van Ypersele de Strihou, Charles [UCL] Miyata, Toshio

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Journal of obesity" - Vol. 2010, no.Epub 2010 Feb 17, p. Epub 2010 Feb 17 (2010)
Peer reviewed yes
issn 0307-0565
Publication status Publié
Affiliations UCL - SSS/IREC/NEFR - Pôle de Néphrologie
UCL - (SLuc) Service de néphrologie
Links
  1. Sarafidis Pantelis A., Ruilope Luis M., Insulin Resistance, Hyperinsulinemia, and Renal Injury: Mechanisms and Implications, 10.1159/000093632
  2. Trovati M., Optimization of Hypolipidemic and Antiplatelet Treatment in the Diabetic Patient with Renal Disease, 10.1097/01.asn.0000093238.09114.40
  3. Sarafidis P.A., Bakris G.L., Protection of the kidney by thiazolidinediones: An assessment from bench to bedside, 10.1038/sj.ki.5001620
  4. Remuzzi G., Prevention and Treatment of Diabetic Renal Disease in Type 2 Diabetes: The BENEDICT Study, 10.1681/asn.2005121324
  5. Fioretto P., Renal Protection in Diabetes: Role of Glycemic Control, 10.1681/asn.2005121343
  6. Locatelli F., Renal Manifestations in the Metabolic Syndrome, 10.1681/asn.2005121332
  7. Izzedine H., Coupaye M., Reach I., Deray G., Gastric bypass and resolution of proteinuria in an obese diabetic patient, 10.1111/j.1464-5491.2005.01679.x
  8. Saiki A, Nagayama D, Ohhira M, Endoh K, Ohtsuka M, Koide N, Oyama T, Miyashita Y, Shirai K, Effect of weight loss using formula diet on renal function in obese patients with diabetic nephropathy, 10.1038/sj.ijo.0803009
  9. Morales Enrique, Valero MaAngeles, León Miguel, Hernández Eduardo, Praga Manuel, Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies, 10.1053/ajkd.2003.50039
  10. Kidney International. Supplement, S137 (2005)
  11. Nangaku M., Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model, 10.1097/01.asn.0000062961.76776.c1
  12. Ohtomo S., Izuhara Y., Takizawa S., Yamada N., Kakuta T., van Ypersele de Strihou C., Miyata T., Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model, 10.1038/sj.ki.5002570
  13. American Journal of Clinical Nutrition, 75, 11 (2002)
  14. Bahadori B., Yazdani-Biuki B., Krippl P., Brath H., Uitz E., Wascher T. C., Low-fat, high-carbohydrate (low-glycaemic index) diet induces weight loss and preserves lean body mass in obese healthy subjects: results of a 24-week study, 10.1111/j.1463-1326.2004.00445.x
  15. American Journal of Physiology, 276, F218 (1999)
  16. Wisse B. E., The Inflammatory Syndrome: The Role of Adipose Tissue Cytokines in Metabolic Disorders Linked to Obesity, 10.1097/01.asn.0000141966.69934.21
  17. Kadowaki T., Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome, 10.1172/jci29126
  18. Wiecek A., Adamczak M., Chudek J., Adiponectin--an adipokine with unique metabolic properties, 10.1093/ndt/gfl814
  19. Schena F. P., Pathogenetic Mechanisms of Diabetic Nephropathy, 10.1681/asn.2004110970
  20. Ziyadeh F. N., Mediators of Diabetic Renal Disease: The Case for TGF-  as the Major Mediator, 10.1097/01.asn.0000093460.24823.5b
  21. Pawluczyk Izabella Z.A., Harris Kevin P.G., Cytokine interactions promote synergistic fibronectin accumulation by mesangial cells, 10.1046/j.1523-1755.1998.00965.x
  22. Phillips Aled O., Topley Nicholas, Steadman Robert, Morrisey Kimberley, Williams John D., Induction of TGF-β1 synthesis in D-glucose primed human proximal tubular cells by IL-1β and TNFα, 10.1038/ki.1996.470
  23. Horie K, Miyata T, Maeda K, Miyata S, Sugiyama S, Sakai H, van Ypersole de Strihou C, Monnier V M, Witztum J L, Kurokawa K, Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy., 10.1172/jci119853
  24. Journal of the American Society of Nephrology, 10, 822 (1999)
  25. Bohlender J. M., Advanced glycation end products and the kidney, 10.1152/ajprenal.00398.2004
  26. Lee H. B., Reactive Oxygen Species-Regulated Signaling Pathways in Diabetic Nephropathy, 10.1097/01.asn.0000077410.66390.0f
  27. Ohtomo S., Nangaku M., Izuhara Y., Takizawa S., Strihou C. v. Y. d., Miyata T., Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model, 10.1093/ndt/gfm715
  28. Nangaku M., Izuhara Y., Usuda N., Inagi R., Shibata T., Sugiyama S., Kurokawa K., van Ypersele de Strihou C., Miyata T., In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy, 10.1093/ndt/gfi096
  29. Izuhara Y., Renoprotective Properties of Angiotensin Receptor Blockers beyond Blood Pressure Lowering, 10.1681/asn.2005050522
  30. Yokoi H., Mukoyama M., Mori K., Kasahara M., Suganami T., Sawai K., Yoshioka T., Saito Y., Ogawa Y., Kuwabara T., Sugawara A., Nakao K., Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice, 10.1038/sj.ki.5002722
  31. Guha M., Xu Z.-G., Tung D., Lanting L., Natarajan R., Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes, 10.1096/fj.06-6713com
  32. LEE HI BAHL, HA HUNJOO, Plasminogen activator inhibitor-1 and diabetic nephropathy, 10.1111/j.1440-1797.2005.00449.x
  33. Kidney International. Supplement, S98 (2005)
  34. Okada S., Shikata K., Matsuda M., Ogawa D., Usui H., Kido Y., Nagase R., Wada J., Shikata Y., Makino H., Intercellular Adhesion Molecule-1-Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes, 10.2337/diabetes.52.10.2586
  35. Ina Keisuke, Kitamura Hirokazu, Okeda Toshimitsu, Nagai Kaoruko, Liu Zhong Y, Matsuda Midori, Fujikura Yoshihisa, Vascular cell adhesion molecule-l expression in the renal interstitium of diabetic KKAy mice, 10.1016/s0168-8227(99)00011-x
  36. Clinical Nephrology, 64, 12 (2005)
  37. Yilmaz Mahmut Ilker, Sonmez Alper, Caglar Kayser, Gok Deniz Engin, Eyileten Tayfun, Yenicesu Müjdat, Acikel Cengizhan, Bingol Necati, Kilic Selim, Oguz Yusuf, Vural Abdulgaffar, Peroxisome Proliferator-Activated Receptor γ (PPAR-γ) Agonist Increases Plasma Adiponectin Levels in Type 2 Diabetic Patients with Proteinuria, 10.1385/endo:25:3:207
  38. Ohashi K., Iwatani H., Kihara S., Nakagawa Y., Komura N., Fujita K., Maeda N., Nishida M., Katsube F., Shimomura I., Ito T., Funahashi T., Exacerbation of Albuminuria and Renal Fibrosis in Subtotal Renal Ablation Model of Adiponectin-Knockout Mice, 10.1161/atvbaha.107.147645
  39. Scott S., Loera S., Tessler C., Chu P., Weiss L., Hardy J., Rahbar S., Figarola J. L., LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats, 10.1007/s00125-003-1162-0
  40. Degenhardt Thorsten P., Alderson Nathan L., Arrington David D., Beattie Robert J., Basgen John M., Steffes Michael W., Thorpe Suzanne R., Baynes John W., Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat, 10.1046/j.1523-1755.2002.00207.x
  41. Thallas-Bonke V., Lindschau C., Rizkalla B., Bach L. A., Boner G., Meier M., Haller H., Cooper M. E., Forbes J. M., Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C- -Dependent Pathway, 10.2337/diabetes.53.11.2921
  42. Journal of the American Society of Nephrology, 12, 2098 (2001)
  43. HA HUNJOO, LEE HI BAHL, Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney, 10.1111/j.1440-1797.2005.00448.x
  44. Kidney International. Supplement, S17 (2007)
  45. McCormick M. L., Gavrila D., Weintraub N. L., Role of Oxidative Stress in the Pathogenesis of Abdominal Aortic Aneurysms, 10.1161/01.atv.0000257552.94483.14
  46. Jiang T., Wang X. X., Scherzer P., Wilson P., Tallman J., Takahashi H., Li J., Iwahashi M., Sutherland E., Arend L., Levi M., Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy, 10.2337/db06-1642
  47. Laboratory Investigation, 60, 433 (1989)
  48. Bosma R.J. , Krikken J.A. , Homan van der Heide J.J., de Jong P.E., Navis G.J. , Obesity and Renal Hemodynamics, Contributions to Nephrology (2006) ISBN:3805581645 p.184-202, 10.1159/000095329
  49. American Journal of Physiology, 256, F224 (1989)
Bibliographic reference Ohtomo, Shuichi ; Izuhara, Yuko ; Nangaku, Masaomi ; Dan, Takashi ; Ito, Sadayoshi ; et. al. Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model.. In: Journal of obesity, Vol. 2010, no.Epub 2010 Feb 17, p. Epub 2010 Feb 17 (2010)
Permanent URL http://hdl.handle.net/2078.1/125380