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Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat.

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Westin, B David Walker, Suellen M Deumens, Ronald [UCL] Grafe, Marjorie Yaksh, Tony L

The therapeutic ratio for intrathecal morphine (toxic dose/antinociceptive dose) was at least 300 at P3 and at least 20 at P21 (latter doses limited by side effects). These data provide relative efficacy and safety for comparison with other analgesic preparations and contribute supporting evidence for the validity of this preclinical neonatal safety model.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Anesthesiology" - Vol. 113, no.1, p. 183-99 (2010)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins ((United States) Philadelphia)
issn 0003-3022
e-issn 1528-1175
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Analgesics, Opioid ; Models, Animal ; Morphine ; Neuroglia ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Spinal Cord ; Animals ; Animals, Newborn ; Apoptosis ; Dose-Response Relationship, Drug ; Female ; Gait ; Injections, Spinal ; Male
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Bibliographic reference Westin, B David ; Walker, Suellen M ; Deumens, Ronald ; Grafe, Marjorie ; Yaksh, Tony L. Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat.. In: Anesthesiology, Vol. 113, no.1, p. 183-99 (2010)
Permanent URL http://hdl.handle.net/2078.1/125352