Herman, C.
[ULB]
Debaste, F.
[ULB]
Halloin, V.
[ULB]
Leyssens, Tom
[UCL]
Line, A.
[ULB]
Haut, B.
[ULB]
This paper proposes an experimental method, based on the Metzner and Otto concept, for the on-line measurement of the apparent viscosity of a crystal slurry during a crystallization process. The first step of this procedure consists of the determination of the N p-Re-Fr relation for Newtonian liquids, for two impeller-tank configurations, chosen such that this relation is a bijective one. This is achieved both experimentally and numerically, using Computational Fluid Dynamics. In the second step of the procedure, the same impeller-tank configurations are used for the determination of the evolution of the apparent viscosity of the crystal slurry (non-Newtonian liquid) during a reference pharmaceutical crystallization process (Etiracetam - UCB). The paper concludes on the influence of the Particle Size Distribution of the crystals on the apparent viscosity of the suspension. For a given crystal mass fraction, the bigger the crystals are - and then the less abundant they are - and the smaller the span is, the smaller the apparent viscosity of the suspension is. © 2009 WIT Press.
Bibliographic reference |
Herman, C. ; Debaste, F. ; Halloin, V. ; Leyssens, Tom ; Line, A. ; et. al. Computational and experimental methods for the on-line measurement of the apparent viscosity of a crystal suspension.5th International Conference on Computational and Experimental Methods in Multiphase and Complex Flow (New Forest (UK), du 15/06/2009 au 17/06/2009). In: WIT Transactions on Engineering Sciences, Vol. 63, no.--, p. 15-26 (2009) |
Permanent URL |
http://hdl.handle.net/2078.1/125308 |