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Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

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Schleiermacher, G Michon, J Ribeiro, A Pierron, G Mosseri, V Brichard, Bénédicte [UCL] Couturier, J

In infants with stage 4s MYCN-non-amplified NB, a SCA genomic profile identifies patients who will require upfront treatment even in the absence of other clinical indication for therapy, whereas in infants with localised unresectable NB, a genomic profile characterised by the absence of SCA identifies patients in whom treatment reduction might be possible. These findings will be implemented in a future international trial.

Document type Article de périodique (Journal article)
Access type Accès interdit
Publication date 2011
Language Anglais
Journal information "British journal of cancer" - Vol. 105, no.12, p. 1940-8 (2011)
Peer reviewed yes
issn 0007-0920
Affiliation UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique
MESH Subject Chromosome Aberrations ; Survival Analysis ; Humans ; Infant ; Neuroblastoma ; Nuclear Proteins ; Oncogene Proteins ; Prognosis ; Prospective Studies ; Recurrence
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Bibliographic reference Schleiermacher, G ; Michon, J ; Ribeiro, A ; Pierron, G ; Mosseri, V ; et. al. Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).. In: British journal of cancer, Vol. 105, no.12, p. 1940-8 (2011)
Permanent URL http://hdl.handle.net/2078/125164