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Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations.

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Wiendl, H Toyka, K V Rieckmann, P Gold, R Sindic, Christian [UCL]

This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2008
Language Anglais
Journal information "Journal of neurology" - Vol. 255, no.10, p. 1449-63 (2008)
Peer reviewed yes
issn 0340-5354
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Antibodies, Monoclonal ; Magnetic Resonance Imaging ; Mitoxantrone ; Multiple Sclerosis ; Peptides ; Plasmapheresis ; Randomized Controlled Trials as Topic ; Societies ; Antibodies, Monoclonal, Humanized ; Azathioprine ; Europe ; Health Planning Guidelines ; Humans ; Immunoglobulins, Intravenous ; Immunologic Factors ; Interferon-beta
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Bibliographic reference ; Wiendl, H ; Toyka, K V ; Rieckmann, P ; Gold, R ; et. al. Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations.. In: Journal of neurology, Vol. 255, no.10, p. 1449-63 (2008)
Permanent URL http://hdl.handle.net/2078.1/125004