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Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.

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Cohen, Jeffrey A Barkhof, Frederik Comi, Giancarlo Hartung, Hans-Peter Khatri, Bhupendra O Sindic, Christian [UCL]

This trial showed the superior efficacy of oral fingolimod with respect to relapse rates and MRI outcomes in patients with multiple sclerosis, as compared with intramuscular interferon beta-1a. Longer studies are needed to assess the safety and efficacy of treatment beyond 1 year. (ClinicalTrials.gov number, NCT00340834.)

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2010
Language Anglais
Journal information "New England Journal of Medicine" - Vol. 362, no.5, p. 402-15 (février 2010)
Peer reviewed yes
Publisher Massachusetts Medical Society ((United States) [S.l.])
issn 0028-4793
e-issn 1533-4406
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Administration, Oral ; Humans ; Immunosuppressive Agents ; Injections, Intramuscular ; Intention to Treat Analysis ; Interferon-beta ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting ; Propylene Glycols ; Adolescent ; Sphingosine ; Statistics, Nonparametric ; Young Adult ; Adult ; Arrhythmias, Cardiac ; Brain ; Disability Evaluation ; Disease Progression ; Double-Blind Method ; Female
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Bibliographic reference Cohen, Jeffrey A ; Barkhof, Frederik ; Comi, Giancarlo ; Hartung, Hans-Peter ; Khatri, Bhupendra O ; et. al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.. In: New England Journal of Medicine, Vol. 362, no.5, p. 402-15 (février 2010)
Permanent URL http://hdl.handle.net/2078.1/124998