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Cerebral peritumoral oedema study: Does a single dynamic MR sequence assessing perfusion and permeability can help to differentiate glioblastoma from metastasis?

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Lehmann, Pierre Saliou , Guillaume de Marco , Giovanni Monet , Pauline El Sankari, Souraya [UCL] Ducreux , Denis

Our purpose was to differentiate glioblastoma from metastasis using a single dynamic MR sequence to assess perfusion and permeability parameters. 24 patients with glioblastoma or cerebral metastasis with peritumoral oedema were recruited and explored with a 3T MR unit. Post processing used DPTools software. Regions of interest were drawn around contrast enhancement to assess relative cerebral blood volume and permeability parameters. Around the contrast enhancement Glioblastoma present high rCBV with modification of the permeability, metastasis present slight modified rCBV without modification of permeability. In conclusion, peritumoral T2 hypersignal exploration associating morphological MR and functional MR parameters can help to differentiate cerebral metastasis from glioblastoma.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "European Journal of Radiology" - Vol. 81, no.3, p. 522-527 (2012)
Peer reviewed yes
Publisher Elsevier Ireland Ltd ((Ireland) Shannon)
issn 0720-048X
e-issn 1872-7727
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service de neurologie
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Bibliographic reference Lehmann, Pierre ; Saliou , Guillaume ; de Marco , Giovanni ; Monet , Pauline ; El Sankari, Souraya ; et. al. Cerebral peritumoral oedema study: Does a single dynamic MR sequence assessing perfusion and permeability can help to differentiate glioblastoma from metastasis?. In: European Journal of Radiology, Vol. 81, no.3, p. 522-527 (2012)
Permanent URL http://hdl.handle.net/2078.1/124928