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DOSY-NMR analysis of ring-closing metathesis (RCM) products from β-lactam precursors

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Sliwa, Aline [UCL] Marchand-Brynaert, Jacqueline [UCL] Luhmer, Michel [UCL]

The discrimination between cyclomonomers and various oligomers formed during a ring-closing metathesis (RCM) process is not an easy task. Their 1H NMR patterns are often very similar, and the use of mass spectrometry techniques is usually recommended. Here, we show that the DOSY-NMR method is a reliable tool to help in the identification of cyclomonomers versus cyclodimers by comparing the translational diffusion coefficient of the compounds issued from RCM reactions with the diffusion coefficient of their respective precursors. © 2011 John Wiley & Sons, Ltd.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Magnetic Resonance in Chemistry" - Vol. 49, no.12, p. 812-815 (2011)
Peer reviewed yes
Publisher Wiley
issn 0749-1581
Publication status Publié
Affiliation UCL - SST/IMCN/MOST - Molecules, Solids and Reactivity
Keywords ; Β-lactams ; 1H ; Cyclodimers ; DOSY ; NMR ; RCM
Links
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Bibliographic reference Sliwa, Aline ; Marchand-Brynaert, Jacqueline ; Luhmer, Michel. DOSY-NMR analysis of ring-closing metathesis (RCM) products from β-lactam precursors. In: Magnetic Resonance in Chemistry, Vol. 49, no.12, p. 812-815 (2011)
Permanent URL http://hdl.handle.net/2078.1/124452