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LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.

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Sarker, M R Sory, M P Boyd, A P Iriarte, M. Cornelis, G R

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 1998
Journal information "Infection and immunity" - Vol. 66, no. 6, p. 2976-9 (1998)
Peer reviewed yes
issn 0019-9567
Publication status Publié
Affiliation UCL
MESH Subject Bacterial Outer Membrane Proteins - metabolism ; Bacterial Proteins - genetics - metabolism ; Bacterial Toxins - metabolism ; Biological Transport ; Cytotoxins - metabolism ; Eukaryotic Cells - microbiology ; Hela Cells - microbiology ; Humans ; Macrophages - microbiology ; Mutation ; Pore Forming Cytotoxic Proteins ; Protein Tyrosine Phosphatases - metabolism ; Yersinia enterocolitica - genetics - metabolism - pathogenicity
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Bibliographic reference Sarker, M R ; Sory, M P ; Boyd, A P ; Iriarte, M. ; Cornelis, G R. LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.. In: Infection and immunity, Vol. 66, no. 6, p. 2976-9 (1998)
Permanent URL http://hdl.handle.net/2078.1/12432