Monteyne, Philippe
Meite, Mory
Coutelier, Jean-Paul
[UCL]
Immunosuppression, occurring naturally with aging, or experimentally after cyclophosphamide treatment or irradiation, is required for the development in C58 mice infected with lactate dehydrogenase-elevating virus (LDV) of a severe polioencephalomyelitis that is caused by viral destruction of anterior horn neurons. Here it is shown that depletion of T helper lymphocytes by administration of an anti-CD4 antibody was followed by a progressive paralysis typical of polioencephalomyelitis in C58/J mice inoculated with a neurovirulent strain of LDV. Although it was clear that other cell subsets are also required to assure complete protection of genetically-susceptible mice, our results show that T helper lymphocytes play a major role in the prevention of LDV-induced polioencephalomyelitis. The mechanisms by which these cells confer this protection remain however to be determined.
Bibliographic reference |
Monteyne, Philippe ; Meite, Mory ; Coutelier, Jean-Paul. Involvement of CD4+ cells in the protection of C58 mouse against polioencephalomyelitis induced by lactate dehydrogenase-elevating virus. In: Journal of NeuroVirology, Vol. 3, no. 5, p. 380-384 (1997) |
Permanent URL |
http://hdl.handle.net/2078.1/12383 |