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Radioimmunotherapy with radioactive nanoparticles: First results of dosimetry for vascularized and necrosed solid tumors

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Bouchat, Virginie Nuttens, Vincent Lucas, Stéphane Michiels, Carine Masereel, Bernard [UNamur] Feron, Olivier [UCL] Gallez, Bernard [UCL] Vander Borght, Thierry [UCL]

Radioimmunotherapy uses monoclonal antibodies that are still labeled with only one radioactive atom. The aim of this paper is to assess, by means of MCNPX simulations, the doses delivered around and throughout a solid tumor when the radioactive atom linked to each antibody is replaced by a 5 nm diameter nanoparticle composed of numerous radionuclides. A new model for a spherical vascularized tumor has been developed in which the antibody distributions inside the tumor can be uniform or heterogeneous. It is also possible to simulate a central necrotic core inside the tumor where the concentration of radiolabeled antibodies is assumed to be zero. Dosimetry calculations have been performed for the beta-emitting radionuclide Y290 O3. Preliminary results show that the irregularity of vasculature and the presence of a necrotic core have a noticeable influence on the deposited dose profiles. Moreover, with a total activity of 5 and 34 MBq for tumor radii of 0.5 and 1.0 cm, respectively, viable tumor cells can receive doses of up to 50 Gy, even if high nonuniformity of the total activity is observed in the tumor. These simulations still require accurate information about antibody characteristics and necrosis sizes but clearly confirm that the use of monoclonal antibodies conjugated to nanoparticles could lead to a considerable enhancement of treatment efficacy against cancer. © 2007 American Association of Physicists in Medicine.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2007
Language Anglais
Journal information "Medical Physics" - Vol. 34, no. 11, p. 4504-4513 (2007)
Peer reviewed yes
Publisher American Association of Physicists in Medicine
issn 0094-2405
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/FARM - Ecole de pharmacie
UCL - (SLuc) Service de médecine nucléaire
Keywords Radioimmunotherapy ; Dosimetry ; Monte Carlo ; Tumor model ; Nanomedicine
Links
  1. Goldenberg, J. Nucl. Med., 43, 693 (2002)
  2. Goldenberg, Q. J. Nucl. Med. Mol. Imaging, 50, 248 (2006)
  3. Waldmann Thomas A., Immunotherapy: past, present and future, 10.1038/nm0303-269
  4. Carmeliet Peter, Angiogenesis in health and disease, 10.1038/nm0603-653
  5. Folkman Judah, Angiogenesis in cancer, vascular, rheumatoid and other disease, 10.1038/nm0195-27
  6. Ahlskog, Q. J. Nucl. Med. Mol. Imaging, 50, 296 (2006)
  7. Gruaz-Guyon A., Raguin O., Barbet J., Recent Advances in Pretargeted Radioimmunotherapy, 10.2174/0929867053363225
  8. Postema Ernst J., Boerman Otto C., Oyen Wim J., Raemaekers John M., Corstens Frans H., Radioimmunotherapy of B-cell non-Hodgkin's lymphoma, 10.1007/s002590100570
  9. Witzig Thomas, Radioimmunotherapy for patients with relapsed B-cell non-Hodgkin lymphoma, 10.1007/s002800100312
  10. White Christine, Berlfein Judy, Grillo-Lopez Antonio, Antibody-Targeted Immunotherapy for Treatment of Non-Hodgkins Lymphoma, 10.2174/1389201003378889
  11. M. Goldenberg David, The role of radiolabeled antibodies in the treatment of non-Hodgkin's lymphoma: the coming of age of radioimmunotherapy, 10.1016/s1040-8428(01)00108-1
  12. Wiseman Gregory A, White Christine A, Sparks Richard B, Erwin William D, Podoloff Donald A, Lamonica Dominick, Bartlett Nancy L, Anthony Parker J, Dunn William L, Spies Stewart M, Belanger Richard, Witzig Thomas E, Leigh Bryan R, Biodistribution and dosimetry results from a phase III prospectively randomized controlled trial of Zevalin™ radioimmunotherapy for low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma, 10.1016/s1040-8428(01)00107-x
  13. Bethge Wolfgang A., Sandmaier Brenda M., Targeted Cancer Therapy Using Radiolabeled Monoclonal Antibodies, 10.1177/153303460500400407
  14. Govindan Serengulam V., Griffiths Gary L., Hansen Hans J., Horak Ivan D., Goldenberg David M., Cancer Therapy with Radiolabeled and Drug/Toxin-conjugated Antibodies, 10.1177/153303460500400406
  15. Sharkey, J. Nuc. Med. Treat., 46, 115S (2005)
  16. Goldenberg, Cancer Immunol. Immunother, 52, 281 (2003)
  17. Peng D.L., Hihara T., Sumiyama K., Structure and magnetic properties of FePt alloy cluster-assembled films, 10.1016/j.jmmm.2003.10.028
  18. Thomann A.L., Salvetat J.P., Breton Y., Andreazza-Vignolle C., Brault P., Thermal stability of metal nanoclusters formed by low-pressure plasma sputtering, 10.1016/s0040-6090(02)01279-8
  19. Naudon A, Babonneau D, Thiaudière D, Lequien S, Grazing-incidence small-angle X-ray scattering applied to the characterization of aggregates in surface regions, 10.1016/s0921-4526(99)01894-3
  20. Saito Yahachi, Nanoparticles and filled nanocapsules, 10.1016/0008-6223(95)00026-a
  21. Moghimi, Pharmacol. Rev., 53, 283 (2001)
  22. Moghimi S.M., Szebeni J., Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties, 10.1016/s0163-7827(03)00033-x
  23. Moghimi S. Moein, Hunter A. Christy, 10.1023/a:1011054123304
  24. OWENSIII D, PEPPAS N, Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles, 10.1016/j.ijpharm.2005.10.010
  25. Moghimi S. M., Nanomedicine: current status and future prospects, 10.1096/fj.04-2747rev
  26. Gref R, Lück M, Quellec P, Marchand M, Dellacherie E, Harnisch S, Blunk T, Müller R.H, ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption, 10.1016/s0927-7765(99)00156-3
  27. Yi Yilwoong, Kim Jae Hong, Kang Hye-Won, Oh Hun Seung, Kim Sung Wan, Seo Min Hyo, A Polymeric Nanoparticle Consisting of mPEG-PLA-Toco and PLMA-COONa as a Drug Carrier: Improvements in Cellular Uptake and Biodistribution, 10.1007/s11095-004-1187-1
  28. McNeil S. E., Nanotechnology for the biologist, 10.1189/jlb.0205074
  29. McNeil S. E., Nanotechnology for the biologist, 10.1189/jlb.0205074
  30. Yokoyama Masayuki, Drug targeting with nano-sized carrier systems, 10.1007/s10047-005-0285-0
  31. Parak Wolfgang J, Pellegrino Teresa, Plank Christian, Labelling of cells with quantum dots, 10.1088/0957-4484/16/2/r01
  32. Wu Xingyong, Liu Hongjian, Liu Jianquan, Haley Kari N., Treadway Joseph A., Larson J Peter, Ge Nianfeng, Peale Frank, Bruchez Marcel P., Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots, 10.1038/nbt764
  33. Gao Xiaohu, Cui Yuanyuan, Levenson Richard M, Chung Leland W K, Nie Shuming, In vivo cancer targeting and imaging with semiconductor quantum dots, 10.1038/nbt994
  34. Rhyner Matthew N, Smith Andrew M, Gao Xiaohu, Mao Hui, Yang Lily, Nie Shuming, Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging, 10.2217/17435889.1.2.209
  35. Kemshead, Mol. Cell. Biochem., 67, 11 (1985)
  36. Choesmel Valérie, Anract Philippe, Høifødt Hanne, Thiery Jean-Paul, Blin Nathalie, A relevant immunomagnetic assay to detect and characterize epithelial cell adhesion molecule-positive cells in bone marrow from patients with breast carcinoma : Immunomagnetic purification of micrometastases, 10.1002/cncr.20391
  37. Loo Christopher, Lowery Amanda, Halas Naomi, West Jennifer, Drezek Rebekah, Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy, 10.1021/nl050127s
  38. Hirsch L. R., Stafford R. J., Bankson J. A., Sershen S. R., Rivera B., Price R. E., Hazle J. D., Halas N. J., West J. L., Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance, 10.1073/pnas.2232479100
  39. Wang Gangli, Huang Tao, Murray Royce W., Menard Laurent, Nuzzo Ralph G., Near-IR Luminescence of Monolayer-Protected Metal Clusters, 10.1021/ja0452471
  40. Nuttens, Appl. Radiat. Isot.
  41. Ribatti Domenico, Vacca Angelo, Dammacco Franco, The Role of the Vascular Phase in Solid Tumor Growth: A Historical Review, 10.1038/sj.neo.7900038
  42. Folkman J., ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS, 10.1084/jem.133.2.275
  43. Sutherland R., Cell and environment interactions in tumor microregions: the multicell spheroid model, 10.1126/science.2451290
  44. Cremonesi, Q. J. Nucl. Med. Mol. Imaging, 50, 288 (2006)
  45. Howell Roger W., Rao Dandamudi V., Sastry Kandula S. R., Macroscopic dosimetry for radioimmunotherapy: Nonuniform activity distributions in solid tumors : Macroscopic dosimetry for radioimmunotherapy, 10.1118/1.596404
  46. van Dieren E.B., Plaizier M.A.B.D., van Lingen A., Roos J.C., Barendsen G.W., Teule G.J.J., Absorbed dose distribution of the auger emitters 67Ga and 125I and the β-emitters 67Cu, 90Y, 131I, and 186Re as a function of tumor size, uptake, and intracellular distribution, 10.1016/s0360-3016(96)00280-5
  47. Tissue substitutes in radiation dosimetry and measurement 1989
  48. Lin Shiming, Lee Chih-Kung, Lin Yin-Hang, Lee Shih-Yuan, Sheu Bor-Ching, Tsai Jui-Chang, Hsu Su-Ming, Homopolyvalent antibody–antigen interaction kinetic studies with use of a dual-polarization interferometric biosensor, 10.1016/j.bios.2006.02.011
  49. San Paulo Alvaro, García Ricardo, High-Resolution Imaging of Antibodies by Tapping-Mode Atomic Force Microscopy: Attractive and Repulsive Tip-Sample Interaction Regimes, 10.1016/s0006-3495(00)76712-9
  50. Cser L., Gladkib I. A., Franek F., Ostanevich Yu. M., Investigation of antibody structures by scattering techniques, 10.1007/bf01525028
  51. Dvorak, Cancer Cells, 3, 77 (1991)
  52. Döme Balázs, Paku Sándor, Somlai Beáta, Tímár József, Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance : Angiogenesis of malignant melanoma, 10.1002/path.1124
  53. Beli�n Jeroen A. M., van Diest Paul J., Baak Jan P. A., Relationships between vascularization and proliferation in invasive breast cancer, 10.1002/(sici)1096-9896(199911)189:3<309::aid-path457>3.0.co;2-0
  54. Schlueter Claudia, Weber Holger, Meyer Britta, Rogalla Piere, Röser Kerstin, Hauke Sven, Bullerdiek Jörn, Angiogenetic Signaling through Hypoxia, 10.1016/s0002-9440(10)62344-9
  55. Lee D.-S., Rieger H., Bartha K., Flow Correlated Percolation during Vascular Remodeling in Growing Tumors, 10.1103/physrevlett.96.058104
  56. Bartha K., Rieger H., Vascular network remodeling via vessel cooption, regression and growth in tumors, 10.1016/j.jtbi.2006.01.022
  57. Humm, J. Nucl. Med., 31, 75 (1990)
  58. D. B. Pelowitz MCNPX User's Manual, Version 2.5.0 2005
  59. Reynaert N., Palmans H., Thierens H., Jeraj R., Parameter dependence of theMCNPelectron transport in determining dose distributions, 10.1118/1.1508798
  60. Schaart Dennis R, Jansen Jan Th M, Zoetelief Johannes, Leege Piet F A de, A comparison of MCNP4C electron transport with ITS 3.0 and experiment at incident energies between 100 keV and 20 MeV: influence of voxel size, substeps and energy indexing algorithm, 10.1088/0031-9155/47/9/303
  61. Karnami, Clin. Cancer Res., 9, 3821s (2003)
  62. Jekunen Antti, Kairemo Kalevi, Karnani Päivi, In Vivo Modulators of Antibody Kinetics, 10.3109/02841869609101640
  63. Palm, J. Nucl. Med., 44, 1148 (2003)
  64. Lee, Cancer Res., 61, 4474 (2001)
  65. Chang, Mol. Cancer Ther., 1, 553 (2002)
  66. Tobinai K., Kobayashi Y., Narabayashi M., Ogura M., Kagami Y., Morishima Y., Ohtsu T., Igarashi T., Sasaki Y., Kinoshita T., Murate T., 10.1023/a:1008265313133
  67. Goldenberg David M., Sharkey Robert M., Paganelli Giovanni, Barbet Jacques, Chatal Jean-François, Antibody Pretargeting Advances Cancer Radioimmunodetection and Radioimmunotherapy, 10.1200/jco.2005.03.8471
Bibliographic reference Bouchat, Virginie ; Nuttens, Vincent ; Lucas, Stéphane ; Michiels, Carine ; Masereel, Bernard ; et. al. Radioimmunotherapy with radioactive nanoparticles: First results of dosimetry for vascularized and necrosed solid tumors. In: Medical Physics, Vol. 34, no. 11, p. 4504-4513 (2007)
Permanent URL http://hdl.handle.net/2078.1/123396