Leclercq, Isabelle
[UCL]
Together with that of obesity, the prevalence of non-alcoholic fatty liver disease is increasing. NAFLD is associated with insulin resistance and participate to the metabolic syndrome. A proportion of NAFLD patient will present a progressive disease characterized by, in addition to steatosis, hepatocellualr damage, chronic inflammation and progressive fibrosis and termed non-alcoholic steatohepatitis (NASH). NAHS is recognized as the hepatic complication of the metabolic syndrome. Its severity is related to fibrosis progression. Pathophysiological mechanisms underlying NASH remain ill-defined, the tools to identify NAFLD patients at risk for NASH progression and validate therapy are lacking. In this review, we concentrate on 2 aspects of NAFLD/NASH pathogenesis: the mechanisms of hepatic insulin resistance and the determinants of fibrosis in the context of metabolic syndrome.
Bibliographic reference |
Leclercq, Isabelle. Non-alcoholic fatty liver disease.Séance de l'Académie Royale belge de Médecine (Palais des Académies, Brussels, Belgium). In: Bulletin et Mémoires de l'Académie Royale Belge de Médecine, Vol. 165, no.3-4, p. 147-155; discussion 155-8 (2010) |
Permanent URL |
http://hdl.handle.net/2078.1/122028 |