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Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.

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George, Jacob Pera, Natasha Phung, Nghi Leclercq, Isabelle [UCL] Yun Hou, Jing Farrell, Geoffrey

The MCD model of 'fibrosing steatohepatitis' replicates the histologic features of human steatohepatitis, and the sequence of steatosis, inflammatory cell injury and fibrogenesis. The temporal sequence is consistent with a concept for involvement of oxidative injury in inflammatory recruitment and pathogenesis of hepatic fibrogenesis.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Language Anglais
Journal information "Journal of Hepatology" - Vol. 39, no. 5, p. 756-764 (2003)
Peer reviewed yes
Publisher Elsevier BV ((Netherlands) Amsterdam)
issn 0168-8278
e-issn 1600-0641
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hépato-gastro-entérologie
MESH Subject Animals ; Male ; Methionine ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Transforming Growth Factor beta ; Up-Regulation ; Choline ; Diet ; Fatty Liver ; Gene Expression ; Hepatocytes ; Lipid Peroxidation ; Liver ; Liver Cirrhosis
Keywords Steatohepatitis ; Hepatic fibrosis ; Lipid peroxidation ; Collagen ; Stellate cells ; Hepatocytes ; Transforming growth factor-beta
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Bibliographic reference George, Jacob ; Pera, Natasha ; Phung, Nghi ; Leclercq, Isabelle ; Yun Hou, Jing ; et. al. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.. In: Journal of Hepatology, Vol. 39, no. 5, p. 756-764 (2003)
Permanent URL http://hdl.handle.net/2078.1/121985