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Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells.

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Hermans, Emmanuel [UCL] Maloteaux, Jean-Marie [UCL]

The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol phosphate cell content. Preincubation of the cells with neurotensin dramatically decreased their response to further stimulation. This diminution, which was time-dependent and not related to the availability of phospholipase C substrate, is though to reflect a progressive homologous desensitization of the recombinant neurotensin receptor.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 1996
Journal information "Biochemical pharmacology" - Vol. 51, no. 12, p. 1749-52 (1996)
Peer reviewed yes
issn 0006-2952
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Animals ; CHO Cells - drug effects ; Cells, Cultured ; Cricetinae ; Hydrolysis ; Neurotensin - pharmacology ; Phosphatidylinositols - metabolism ; Time Factors ; Transfection
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Bibliographic reference Hermans, Emmanuel ; Maloteaux, Jean-Marie. Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells.. In: Biochemical pharmacology, Vol. 51, no. 12, p. 1749-52 (1996)
Permanent URL http://hdl.handle.net/2078.1/12186