Zanou, Nadège
[UCL]
Iwata, Y.
Schakman, Olivier
[UCL]
Lebacq, Jean
[UCL]
Wakabayashi, S.
Gailly, Philippe
[UCL]
Duchenne myopathy is a lethal disease due to the absence of dystrophin, a cytoskeletal protein.
Muscles from dystrophin-deficient mice (mdx) typically present an exaggerated susceptibility to
eccentric work characterized by an important force drop and increased membrane permeability
consecutive to repeated lengthening contractions. The present study shows that mdx muscles are
largely protected from eccentric work-induced damage by overexpressing a dominant negative mutant
of TRPV2 ion channel.
This observation points out the role of TRPV2 channel in the physiopathology of Duchenne muscular
dystrophy.
Bibliographic reference |
Zanou, Nadège ; Iwata, Y. ; Schakman, Olivier ; Lebacq, Jean ; Wakabayashi, S. ; et. al. Essential role of TRPV2 in the sensitivity of dystrophic muscle to eccentric contractions.TRP Congress (Leuven, Belgium). |
Permanent URL |
http://hdl.handle.net/2078.1/121173 |