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Insight into topological and functional relationships of cytochrome c oxidase subunit I of Saccharomyces cerevisiae by means of intragenic complementation.

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Meunier, B. Coster, F Lemarre, P Colson, A M

In yeast, revertants were selected from four respiratory deficient mutants carrying mutations in the cytochrome c oxidase subunit I gene. Intragenic second site mutations revealed amino acids which are functionally complementary to the original mutated position and may be in topological interaction with it. The results provide additional data in favour of the model proposed for the structure of the binuclear centre in proton-motive oxidases.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1993
Journal information "FEBS letters" - Vol. 321, no. 2-3, p. 159-62 (1993)
Peer reviewed yes
issn 0014-5793
Publication status Publié
Affiliation UCL
MESH Subject Amino Acid Sequence ; Base Sequence ; Codon - genetics ; Electron Transport Complex IV - chemistry - metabolism ; Genes, Fungal ; Genetic Complementation Test ; Introns ; Macromolecular Substances ; Models, Structural ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; Protein Structure, Secondary ; Saccharomyces cerevisiae - enzymology - genetics
Links
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Bibliographic reference Meunier, B. ; Coster, F ; Lemarre, P ; Colson, A M. Insight into topological and functional relationships of cytochrome c oxidase subunit I of Saccharomyces cerevisiae by means of intragenic complementation.. In: FEBS letters, Vol. 321, no. 2-3, p. 159-62 (1993)
Permanent URL http://hdl.handle.net/2078.1/12091