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Insight into the interactions between subunits I and II of the cytochrome c oxidase of the yeast Saccharomyces cerevisiae by means of extragenic complementation.

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Meunier, B. Colson, A M

In yeast, revertants were selected from two respiratory deficient mutants carrying mutations in the catalytic subunits of cytochrome oxidase. From a mutant carrying a double mutation in the vicinity of the copper binding pocket in subunit II, two genetically independent revertants were obtained in which the same extragenic reversion mutation was observed, A147V, in the putative helix 4 of subunit I. A comparison with revertants derived from the second deficient mutant, carrying the deficiency mutation, S140L, in the loop 3-4 of subunit I, provides additional data in favour of an interaction between helix 4 of subunit I and subunit II.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1993
Journal information "FEBS letters" - Vol. 335, no. 3, p. 338-40 (1993)
Peer reviewed yes
issn 0014-5793
Publication status Publié
Affiliation UCL
MESH Subject Electron Transport Complex IV - genetics - metabolism ; Genetic Complementation Test ; Mutagenesis ; Saccharomyces cerevisiae - enzymology - genetics
Links
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Bibliographic reference Meunier, B. ; Colson, A M. Insight into the interactions between subunits I and II of the cytochrome c oxidase of the yeast Saccharomyces cerevisiae by means of extragenic complementation.. In: FEBS letters, Vol. 335, no. 3, p. 338-40 (1993)
Permanent URL http://hdl.handle.net/2078.1/12044