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Bipolar radiofrequency ablation with four electrodes: ex vivo liver experiments and finite element method analysis. Influence of inter-electrode distance on coagulation size and geometry

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Mulier, Stefaan Jiang, Yansheng Wang, Chong Jamart, Jacques [UCL] Marchal, Guy Michel, Luc [UCL] Ni, Yicheng

PURPOSE: The aim of this study was to develop an electrode system with simple needle electrodes which would allow a reliable and predictable ablation zone with radiofrequency ablation (RFA). MATERIALS AND METHODS: In the first step, four parallel electrodes (active length 3 cm, diameter 1.8 mm) were inserted in ex vivo bovine liver. A power of 50 W was applied between two pairs of electrodes for 10 min or until current shut-off due to impedance rise. In the second step, the influence of changing inter-electrode distance on coagulation size and geometry was measured. In the third step, a finite element method (FEM) analysis of the experiment was performed to better understand the experimental findings. RESULTS: A bipolar four-electrode system with templates adjusting the inter-electrode distance was successfully developed for ex vivo experiments. A complete and reliable coagulation zone of a 3 × 2 × 2-cm block was obtained most efficiently with an inter-electrode distance of 2 cm in 5.12 ± 0.71 min. Above 2 cm, coagulation was incomplete due to a too low electric field, as demonstrated by the FEM analysis. CONCLUSIONS: The optimal inter-electrode distance of the present bipolar four-electrode system was 2 cm, allowing a reliable and predictable ablation zone in ex vivo liver. The FEM analysis correctly simulated and explained the findings in ex vivo liver. The experimental set-up may serve as a platform to gain more insight and to optimise the application of RFA by means of four or more simple needle electrodes.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "International Journal of Hyperthermia" - Vol. 28, no. 7, p. 686-697 (2012)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 0265-6736
e-issn 1464-5157
Publication status Publié
Affiliations UCL - (MGD) Service de chirurgie
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - (MGD) Unité de support scientifique
Keywords Bipolar ; experimental ; finite element method ; liver ; radiofrequency ablation
Links
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Bibliographic reference Mulier, Stefaan ; Jiang, Yansheng ; Wang, Chong ; Jamart, Jacques ; Marchal, Guy ; et. al. Bipolar radiofrequency ablation with four electrodes: ex vivo liver experiments and finite element method analysis. Influence of inter-electrode distance on coagulation size and geometry. In: International Journal of Hyperthermia, Vol. 28, no. 7, p. 686-697 (2012)
Permanent URL http://hdl.handle.net/2078.1/120292