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The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes.

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Purnelle, Bénédicte [UCL] Coster, F Goffeau, André [UCL]

A 36 kb fragment from the left arm of chromosome X, located at about 50 kb from the telomere, was sequenced and analysed. The segment contains a new putative ARS, a new tRNA for threonine, remnants of a solo delta and 24 open reading frames (ORFs) numbered from J0310 to J0355. Six of them, NUC1, PRP21 (also called SPP91), CDC6, CRY2, the gene encoding the ribosomal protein S24 and the gene coding for a hypothetical protein of 599 amino acids, have been sequenced previously. Three ORFs show high homology to the yeast gene ACO1 encoding mitochondrial aconitase and to the chromosome III genes YCR34W and YCR37C of unknown function. Three other ORFs show lower but significant homology: a first one to UNP, a gene related to the tre-2 oncogene from mouse and to the gene coding for the yeast deubiquitinating enzyme DOA2; a second one to SLY41, a suppressor of the functional loss of YPT1 and a third one to the gene encoding the proline utilization activator PUT3.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1994
Journal information "Yeast (Chichester, England)" - Vol. 10, no. 9, p. 1235-49 (1994)
Peer reviewed yes
issn 0749-503X
Publication status Publié
Affiliation UCL - AGRO/CABI - Département de chimie appliquée et des bio-industries
MESH Subject Aconitate Hydratase - genetics ; Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Fungal - genetics ; Fungal Proteins - genetics ; Genes, Fungal ; Genome, Fungal ; Humans ; Mice ; Mitochondria - enzymology - genetics ; Molecular Sequence Data ; Open Reading Frames - genetics ; RNA, Fungal - genetics ; RNA, Transfer, Thr - genetics ; Ribosomal Proteins - genetics ; Saccharomyces cerevisiae - enzymology - genetics ; Sequence Analysis ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Telomere - genetics
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Bibliographic reference Purnelle, Bénédicte ; Coster, F ; Goffeau, André. The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes.. In: Yeast (Chichester, England), Vol. 10, no. 9, p. 1235-49 (1994)
Permanent URL http://hdl.handle.net/2078.1/11913