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Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.

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Meunier, Brigitte [UCL] Corbisier-Colson, Anne-Marie [UCL]

In Saccharomyces cerevisiae, diuron blocks the respiratory pathway at the level of the bc1 complex. Two mitochondrially inherited loci, DIU1 and DIU2, located in the cytochrome b gene, and two nuclearly inherited loci, DIU3 and DIU4, have previously been identified. The present work genetically characterizes two double mutants. One mutant, Diu-217, carries two nuclearly inherited mutations, diu3-217a and diu-217b; the second mutant, Diu-783, carries the previously described nuclear mutation diu3-783 and a mitochondrial mutation diu2-783. Each mutation, independent of its location, exhibits a weak diuron resistance. The joint expression of two or three mutations leads to a cumulative or a cooperative enhanced diuron-resistant phenotype.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1989
Journal information "Current genetics" - Vol. 15, no. 2, p. 121-7 (1989)
Peer reviewed yes
issn 0172-8083
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Alleles ; Cytochrome b Group - genetics ; Diuron - pharmacology ; Drug Resistance, Microbial - genetics ; Electron Transport Complex III - genetics ; Exons ; Genes ; Genes, Fungal ; Mitochondria - metabolism ; Mutation ; Phenotype ; Saccharomyces cerevisiae - drug effects - genetics - metabolism
Links
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Bibliographic reference Meunier, Brigitte ; Corbisier-Colson, Anne-Marie. Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.. In: Current genetics, Vol. 15, no. 2, p. 121-7 (1989)
Permanent URL http://hdl.handle.net/2078.1/11588