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Intravital multi-photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules

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Caplanusi, A [UCL] Parreira, Kleber Simônio [UCL] Rezende Lima, W [UCL] Marien, Benoît [UCL] Van Der Smissen, Patrick [UCL] de Diesbach, Philippe [UCL] Devuyst, Olivier [UCL] Courtoy, Pierre J. [UCL]

Understanding renal function requires one to integrate the structural complexity of kidney nephrons and the dynamic nature of their cellular processes. Multi-photon fluorescence microscopy is a state-of-the-art imaging technique for in vivo analysis of kidney tubules structure and function in real time. This study presents visual evidence for several levels of heterogeneity of proximal tubular endocytic uptake in the superficial renal mouse cortex and illustrates the potential of multi-photon microscopy for providing a comprehensive and dynamic portrayal of renal function.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2008
Language Anglais
Journal information "Journal of Cellular and Molecular Medicine : a journal of translational medicine" - Vol. 12, no. 1, p. 351-354 (2008)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. ((United Kingdom) Oxford)
issn 1582-1838
e-issn 1582-4934
Publication status Publié
Affiliations UCL - MD/BICL - Département de biochimie et de biologie cellulaire
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Service de biochimie médicale
MESH Subject Animals ; Endocytosis ; Fluorescent Dyes - pharmacokinetics ; Kidney Tubules, Proximal - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton ; Tissue Distribution
Links
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Bibliographic reference Caplanusi, A ; Parreira, Kleber Simônio ; Rezende Lima, W ; Marien, Benoît ; Van Der Smissen, Patrick ; et. al. Intravital multi-photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules. In: Journal of Cellular and Molecular Medicine : a journal of translational medicine, Vol. 12, no. 1, p. 351-354 (2008)
Permanent URL http://hdl.handle.net/2078.1/11223