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Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus.

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Le-Thi-Phuong, Thao [UCL] Thirion, Gaëtan [UCL] Coutelier, Jean-Paul [UCL]

Two distinct pathways of gamma interferon (IFN-gamma) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN-gamma production and requires the secretion of interleukin-12. This regulation of IFN-gamma production by type I interferons may help to control indirect pathogenesis induced by this cytokine.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2007
Journal information "The Journal of general virology" - Vol. 88, no. Pt 11, p. 3063-3066 (2007)
Peer reviewed yes
Publisher Cambridge University Press for the Society for General Microbiology. ((Great Britain) London)
issn 0022-1317
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Gene Expression Regulation ; Interferon Type I - immunology ; Interferon Type II - biosynthesis ; Interleukin-12 - immunology ; Killer Cells, Natural - immunology ; Lactate dehydrogenase-elevating virus - immunology ; Metabolic Networks and Pathways ; Mice
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Bibliographic reference Le-Thi-Phuong, Thao ; Thirion, Gaëtan ; Coutelier, Jean-Paul. Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus.. In: The Journal of general virology, Vol. 88, no. Pt 11, p. 3063-3066 (2007)
Permanent URL http://hdl.handle.net/2078.1/11153