Van Rossom, Wim
[]
Kishore, Lingam
[]
Robeyns, Koen
[UCL]
Van Meervelt, Luc
[]
Dehaen, Wim
[]
Maes, Wouter
[]
Oxacalix[2]arene[2]quinazoline macrocycles were prepared in good yields, as mixtures of syn and anti isomers, through nucleophilic aromatic substitution cyclocondensation reactions of 2, 4-dichloroquinazolines and m-dihydroxybenzenes. The macrocyclization conditions were optimized and the isomeric ratio was investigated by means of one-step and frag-ment-coupling approaches. The oxacalixarene substitution pattern could easily be varied by altering the dichloroquinazolinyl biselectrophilic and dihydroxyaryl bisnucleophilic building blocks. The solid-state (1, 3-alternate) conformational behavior and the oxacalix[4]arene cavity size were explored by X-ray diffraction studies. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Bibliographic reference |
Van Rossom, Wim ; Kishore, Lingam ; Robeyns, Koen ; Van Meervelt, Luc ; Dehaen, Wim ; et. al. Synthetic exploration of oxacalix[2]arene[2]quinazolines. In: Synthetic exploration of oxacalix[2]arene[2]quinazolines, Vol. 2010, no. 21, p. 4122-4129 (2010) |
Permanent URL |
http://hdl.handle.net/2078.1/107412 |