User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis.

Primary tabs

download
  • Open access
  • PDF
  • 2.29 M
Badot, Valérie [UCL] Galant, Christine [UCL] Nzeusseu Toukap, Adrien [UCL] Théate, Ivan [UCL] Maudoux, Anne-Lise [UCL] Van den Eynde, Benoît [UCL] Durez, Patrick [UCL] Houssiau, Frédéric [UCL] Lauwerys, Bernard [UCL]

To identify markers and mechanisms of resistance to adalimumab therapy, we studied global gene expression profiles in synovial tissue specimens obtained from severe rheumatoid arthritis (RA) patients before and after initiation of treatment.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2009
Language Anglais
Journal information "Arthritis Research & Therapy" - Vol. 11, no. 2, p. R57 (2009)
Peer reviewed yes
Publisher BioMed Central Ltd. ((United Kingdom) London)
issn 1478-6354
e-issn 1478-6362
Publication status Publié
Affiliations UCL - (SLuc) Service de rhumatologie
UCL - MD/MNOP - Département de morphologie normale et pathologique
UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
MESH Subject Adolescent ; Adult ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Synovial Membrane - physiology ; Young Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal - therapeutic use ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy, genetics ; Drug Resistance - genetics ; Female
Links
Bibliographic reference Badot, Valérie ; Galant, Christine ; Nzeusseu Toukap, Adrien ; Théate, Ivan ; Maudoux, Anne-Lise ; et. al. Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis.. In: Arthritis Research & Therapy, Vol. 11, no. 2, p. R57 (2009)
Permanent URL http://hdl.handle.net/2078.1/105734