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Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis : results of a 12-week, phase II, dose-finding study.

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Alten, Rieke [] Gomez-Reino, Juan [] Durez, Patrick [UCL] Beaulieu, Andre [] Sebba, Anthony [] Kellner, Herbert []

Canakinumab is a fully human anti-interleukin IL-1beta monoclonal antibody, being investigated for the treatment of rheumatoid arthritis (RA). This multicenter, phase II, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study investigated the efficacy and safety of canakinumab in patients with active RA despite ongoing therapy at stable doses of methotrexate.

Document type Article de périodique (Journal article) – Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "BMC Musculoskeletal Disorders" - Vol. 12, p. 153 (2011)
Peer reviewed yes
Publisher BioMed Central Ltd. ((United Kingdom) [S.l.])
issn 1471-2474
e-issn 1471-2474
Publication status Publié
Affiliations UCL - (SLuc) Service de rhumatologie
UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
Links
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Bibliographic reference Alten, Rieke ; Gomez-Reino, Juan ; Durez, Patrick ; Beaulieu, Andre ; Sebba, Anthony ; et. al. Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis : results of a 12-week, phase II, dose-finding study.. In: BMC Musculoskeletal Disorders, Vol. 12, p. 153 (2011)
Permanent URL http://hdl.handle.net/2078.1/105512