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Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study.

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Daubioul, Catherine [UCL] Horsmans, Yves [UCL] Lambert, Philippe [UCL] Danse, Etienne [UCL] Delzenne, Nathalie M. [UCL]

OBJECTIVE: In experimental animals, recent results suggest that the addition of inulin-type fructans such as oligofructose (OFS) in the diet decreases triacylglycerol accumulation in the liver tissue. Therefore, we have investigated the effect of daily ingestion of OFS in seven patients with nonalcoholic steatohepatitis (NASH), confirmed by liver biopsies. DESIGN: They received 16 g/day OFS or maltodextrine (placebo) for 8 weeks in a randomized double-blind crossover design. Energy intake, body composition, liver steatosis and blood parameters were analysed after 4 and 8 weeks of dietary supplementation. RESULTS: Compared to placebo, OFS decreased significantly serum aminotransferases, aspartate aminotransferase after 8 weeks, and insulin level after 4 weeks, but this could not be related to significant effect on plasma lipids. CONCLUSION: This pilot study supports the putative interest of OFS in the management of liver diseases associated with abnormal lipid accumulation in humans.

Document type Article de périodique (Journal article) – Clinical Trial, Journal Article, Randomized Controlled Trial
Access type Accès restreint
Publication date 2005
Journal information "European Journal of Clinical Nutrition" - Vol. 59, no. 5, p. 723-726 (2005)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 0954-3007
e-issn 1476-5640
Publication status Publié
Affiliations UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - MD/FARM - Ecole de pharmacie
MESH Subject Aged ; Aspartate Aminotransferases - blood - drug effects ; Biopsy - methods ; Body Composition - physiology ; Cross-Over Studies ; Double-Blind Method ; Energy Intake - physiology ; Fatty Liver - complications - drug therapy - metabolism ; Glucose - metabolism ; Hepatitis - complications - drug therapy - metabolism ; Humans ; Insulin - blood ; Lipid Metabolism ; Liver - drug effects - metabolism - pathology ; Male ; Middle Aged ; Oligosaccharides - pharmacology ; Pilot Projects ; Polysaccharides - administration & dosage ; Time Factors ; Transaminases - blood - drug effects ; Adult
Links
  1. Agrawal S, J. Clin. Gastroenterol., 35, 253 (2002)
  2. Bergman RN, J. Investig. Med., 49, 119 (2001)
  3. Brighenti F, Eur. J. Clin. Nutr., 53, 726 (1999)
  4. Brunt EM, Am. J. Gastroenterol., 94, 2467 (1999)
  5. Chitturi S, Hepatology, 35, 373 (2002)
  6. Daubioul CA, J. Nutr., 132, 967 (2002)
  7. Daubioul CA, J. Nutr., 130, 1314 (2000)
  8. Delzenne NM, Curr. Opin. Lipidol., 13, 61 (2002)
  9. Diraison F, Diabetes Metab., 29, 478 (2003)
  10. Jackson Kim G., Taylor Gary R. J., Clohessy Anna M., Williams Christine M., The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women, 10.1017/s0007114599001087
  11. Kok N, Metabolism, 45, 1547 (1996)
  12. Letexier D, Am J. Clin. Nutr., 77, 559 (2003)
  13. Luyck FH, Diabetes Metab., 26, 98 (2000)
  14. Pagano G, Hepatology, 35, 367 (2002)
  15. Reid AE, Gastroenterology, 121, 710 (2001)
  16. Roberfroid MB, Annu. Rev. Nutr., 18, 117 (1998)
  17. Yu AS, Rev. Gastroenterol. Disord., 2, 11 (2002)
  18. Zafrani ES, Virchows Arch., 444, 3 (2004)
Bibliographic reference Daubioul, Catherine ; Horsmans, Yves ; Lambert, Philippe ; Danse, Etienne ; Delzenne, Nathalie M.. Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study.. In: European Journal of Clinical Nutrition, Vol. 59, no. 5, p. 723-726 (2005)
Permanent URL http://hdl.handle.net/2078.1/10132