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Liver transplantation for chronic graft-versus-host disease: case report with 10-year follow-up.

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Orlando, Giuseppe Ferrant, Augustin [UCL] Schots, Rik Goffette, Pierre [UCL] Mathijs, Jules Danse, Etienne [UCL] Latinne, Dominique [UCL] Lerut, Jan [UCL]

Graft-versus-host disease (GVHD) is a frequent complication of bone marrow transplantation (BMT). Chronic GVHD (cGVHD) may lead to irreversible liver failure. We report a case of successful liver transplantation (LT) for end-stage liver failure because of cGVHD that had developed 22 months after BMT in a 24-year-old male. Re-transplantation was necessary 6 months later because of intrahepatic ischaemic type biliary tract lesions. He is now in excellent condition 10 years after the first transplant. This experience and the review of literature indicate that LT can cure GVHD-related chronic liver failure. Recurrent GVHD in the allograft has not yet been reported.

Document type Article de périodique (Journal article) – Article de recherche – Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review
Publication date 2005
Language Anglais
Journal information "Transplant international : official journal of the European Society for Organ Transplantation" - Vol. 18, no. 1, p. 125-9 (2005)
Peer reviewed yes
issn 0934-0874
Publication status Publié
Affiliations UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Service de radiologie
MESH Subject Adult ; Bone Marrow Transplantation ; Graft vs Host Disease - surgery ; Humans ; Liver Failure - surgery ; Liver Transplantation ; Male ; Time Factors ; Treatment Outcome
Links
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Bibliographic reference Orlando, Giuseppe ; Ferrant, Augustin ; Schots, Rik ; Goffette, Pierre ; Mathijs, Jules ; et. al. Liver transplantation for chronic graft-versus-host disease: case report with 10-year follow-up.. In: Transplant international : official journal of the European Society for Organ Transplantation, Vol. 18, no. 1, p. 125-9 (2005)
Permanent URL http://hdl.handle.net/2078.1/10058